Joseph A. Jakubowski, Atsuhiro Sugidachi. Thienopyridyl and Direct-Acting P2Y 12 Receptor Antagonist Antiplatelet Drugs. 2012:, 141-164. /Joseph A.Jakubowski, AtsuhiroSugidachi. Thienopyridyl and Direct-Acting P2Y 12 Receptor Antagonist Antiplatelet Drugs. 2012:, 141-164. /...
Inhibition of the P2Y12 receptor is a well-established strategy for anti-thrombotic therapy; Plavix®(clopidogrel), an irreversible P2Y12 receptor antagonist, is the number one selling drug on the market for antiplatelet therapy [170]. However, P2Y1 is a relatively new target being explored ...
Selective ligands have been synthesized for most of the P2Y receptors with the most prominent successes attained with highly selective agonist and antagonist molecules for the ADP-activated P2Y1 and P2Y12 receptors. The widely prescribed drug, clopidogrel, which results in irreversible blockade of the...
arethemostimportantdrugsfortreatmentofcardiovasculardiseasesnowadays.Butclopidogrelhasthedis- advantageofslowonset,relativelowefficacy,andpatientswithlow-responseandno-responsewerereported. PrasugrelwasarelativelynewplateletP2Y12receptorantagonist.TRITON-TIMI38studyshowedthatprasugrel ...
Research progress on the mechanism of broad-spectrum antiplatelet effect of novel P2Y12 receptor antagonist ticagrelor ZHAO Kaikai, BAI Junqin, ZHANG Bo ( Department of Cardiology, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116011, China) [ KEY WORDS] P2Y12 receptor antago...
Selatogrel: 一种P2Y12 receptor拮抗剂药物,由Idorsia Ltd. (Idorsia Ltd.)公司最早进行研发,目前全球最高研发状态为临床3期,作用机制: P2Y12 receptor拮抗剂(嘌呤P2Y12受体拮抗剂),治疗领域: 心血管疾病,在研适应症: 急性心肌梗塞,在研机构: Idorsia Pharmaceuticals
Prasugrel: a novel platelet ADP P2Y12 receptor antagonist. A review on its mechanism of action and clinical development. Dominick J Angiolillo,Siva Suryadevara,Piera Capranzano,Theodore A Bass. Expert Opinion on Pharmacotherapy . 2008Angiolillo D J,Suryadevara S,Capranzano P,et al. Prasugrel:...
ClinicalstudyoverviewofplateletP2Y12receptorantagonistsWANGEr— hui,LIUYing.InstituteofPharn~ol— ogyandToxicology,Beijing100850,China 【Abstract】 Asaresultoftheagingpopulation,theincidenceofcardiovascularandcerebrovasculardiseas eshavein— creasedandbecameanimportantreasonleadchinesepeopletodie.Oralantiplateletmedicati...
COX x P2Y12 receptor 作用机制 COX抑制剂[+1] 在研机构 Torrent Pharmaceuticals Ltd. 原研机构 Torrent Pharmaceuticals Ltd. 在研适应症 急性冠状动脉综合征 非在研适应症- 最高研发阶段批准上市 首次获批国家/地区 印度 首次获批日期2016-01-01 1,670 ...
For the detection of inhibitory effects at the P2Y12 receptor, ADP is used as an agonist, with or without the antagonist prostaglandin E1 (PGE1). A dilution of whole blood and 0.9% NaCl is stirred in the test cuvettes, ADP+PGE1 or ADP alone is added, and the increase in electrical ...