根据结构和所抑制的cyclin-CDK复合物的不同,可分为INK4(Inhibitor of CDK4)家族和CIP/KIP家族。INK4家族包括P15,P16,P18,P19等,可特异抑制cyclin-CDK4/6的磷酸化激酶活化而抑制细胞增生。CIP/KIP家族包括P21,P27,P57等,可抑制已知的大多数cyclin-CDK复合物的激酶活性,对G1期的早期与晚期、S期等各期都有...
Control of DNA synthesis and mitosis by the Skp2-p27- Cdk1/2 axis. Mol. Cell 14, 414-416.Pagano M (2004) Control of DNA synthesis and mitosis by the Skp2- p27-Cdk1/2 axis. Mol Cell 14: 414-416Pagano M.Control of DNA synthesis and mitosis by the Skp2- p27-Cdk1/2 axis. ...
周期素依赖激酶1抗体(CDK1) 价格: ￥980/支 产品详情:科淼生物简介温州科淼生物科技有限公司(Whenzhou KeMiao Biological Technology Co.,Ltd)是一家专业从事“产品研发生产,市场销... 纯度:1mg/ml% 包装规格:50ul 用途:仅供科研使用 用途:仅供科研使用 货号:KMA022553R 品牌:KEMOBio 抑制剂相关产品报价 更多...
We have identified PRC1 as a novel binding partner for p27Kip1 (p27). p27 is a cyclin-CDK inhibitor that causes cell cycle arrest in G1. However, p27 has also been involved in the regulation of G2/M progression and cytokinesis, as well as of other cellular processes, including ...
英文名称CDKN1B/p27 KIP 1 中文名称PP27抗体/周期素依赖激酶抑制剂 别名p27 KIP 1; CDN1B_HUMAN; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDKN1B; CDKN1B; CDKN4; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27;...
The cyclin-dependent kinase (Cdk) inhibitor p27 (also known as KIP1) regulates cell proliferation, cell motility and apoptosis. Interestingly, the protein can exert both positive and negative functions on these processes. Diverse post-translational modifications determine the physiological role of p27...
p27Kip1 is a critical modulator of cell proliferation by controlling assembly, localization and activity of cyclin-dependent kinase (CDK). p27Kip1 also plays important roles in malignant transformation, modulating cell movement and interaction with the extracellular matrix. A critical p27Kip1 feature...
We demonstrate by transfection experiments in SaOS-2 cells that p23 induces a G1 phase growth arrest by inhibition of cyclin/CDK2 activity. In summary we describe here a caspase-cleaved form of p27, induced in absence of detectable apoptosis and likely involved in cell cycle regulation....
它们作为调剂亚基,需与特定的CDK结合,才能形成具有活性的全酶而增进细胞周期的进程。 周期依托蛋白激酶家族(cyclin dependent kinase,CDK) 目前发觉7种成员,有不同程度的同源性,故称CDK家族,各成员命名为CDK1,2,3…7。CDK含有催化亚基,但需要cyclin提供调剂亚基才有活性,因此通常以cyclin- CDK复合物形式显现[6]。
As p27 is a potent suppressor of the G1/S transition and activator of apoptosis, we hypothesized that the known requirement of PFKFB3 for cell cycle progression and prevention of apoptosis may be partly due to the ability of F2,6BP to activate Cdks. In this study, we demonstrate that ...