国内批准的进口PD-1药物,包括非小细胞肺癌的K药、O药、T药、I药,小细胞肺癌的罗氏T药。国产药物的临床数据稍慢一些,初步消息是国产PD-1药物与进口PD-1药物疗效相似。 不同的PD-1药物之间作用机制、作用原理一致,但却是完全不同的药,在一线、二线治疗里也存在巨大差...
PD-1/PD-L1抑制剂可特异性阻断PD-1与PD-L1的结合,阻断负向调控信号,重新激活T细胞,从而增强免疫应答[6]。目前已被批准上市的PD-1/PD-L1抑制剂药物主要有Nivolumab、Pem-brolizumab、Atezolizumab等,临床研究结果显示PD-1/PD-L1抑制剂单药或联合Ipilimumab治疗黑...
hPD-1/hCD27(2) 品系全名 C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd27tm2(hCD27)Smoc 目录号 NM-HU-2000096 品系状态 胚胎冻存 加入购物车 导出PDF 基因信息 基因名CD27 基因曾用名 Cd27; S152; Tnfrsf7; Tp55 NCBI ID 21940 MGI ID 88326 Ensembl ID ENSMUSG00000030336 Pubmed CD27 人类同源基因 C...
PD-1免疫检查点抑制在肿瘤免疫治疗领域具有革命性的突破,但是有反应的患者比例较低,原因与活化DC细胞较少导致的T细胞不完全激活有关。DC信号可以通过CD27激动剂增强,Clin Cancer Res近期发表了一篇文章,研究联合CD27激动性抗体是否可以增强抗PD-1/L1的疗效。作者在多种肿瘤模型中比较了抗PD-1/L1. 著录项 来...
PD-1抗体(BP0273)丨体内加大抗小鼠PD-1(CD279) 基本介绍: 29F.1A12单克隆抗体与小鼠PD-1(程序性死亡-1)反应,也称为CD279。PD-1是由Pdcd50基因编码的55-1 kDa细胞表面受体,属于Ig超家族的CD28家族。PD-1在CD4和CD8胸腺细胞以及活化的T和B淋巴细胞和骨髓细胞上短暂表达。PD-1在成功消除抗原后表达下降。
PD-1抗肿瘤活性活化肿瘤免疫治疗协同DC细胞PD-1免疫检查点抑制在肿瘤免疫治疗领域具有革命性的突破,但是有反应的患者比例较低,原因与活化DC细胞较少导致的T细胞不完全激活有关.DC信号可以通过CD27激动剂增强,Clin Cancer Res近期发表了一篇文章,研究联合CD27激动性抗体是否可以增强抗PD-1/L1的疗效.作者在多种肿瘤...
PD-1 expression correlates with loss of CD27 expression on antigen-specific memory CD4+ T cells.Toidi AdekambiChris C. IbegbuAmeeta S. KalokheTianwei YuSusan M. RayJyothi Rengarajan
This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck ...
CD27 is a costimulatory molecule that provides a complementary target to the PD-1/PD-L1 checkpoint axis on T cells. Combining a CD27 agonist antibody with PD-1/PD-L1 blockade has shown synergistic antitumor activity in preclinical models, which led to clinical studies of the combination in ...
OX40- and CD27-Mediated Costimulation Synergizes with Anti-PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence. Journal of immunology. 2015;194(1):125-133.Buchan, S. L., Manzo, T., Flutter, B., Rogel, A., Edwards, N., Zhang, L., Sivakumaran, S., Ghorashian, ...