总之,该文通过构建p21-Cre转基因小鼠模型,提供了一种在体研究p21high细胞生物学特性及作用的有力手段。该模型可以与多种floxed小鼠模型杂交,继而实现在小鼠体内追踪、调节和消除p21high细胞,有助于深入挖掘p21high细胞在自然衰老和各种衰老...
Intermittent clearance of p21high cells improved physical function in 23-month-old mice. p21-Cre mouse model might be a valuable and powerful tool for studying p21high cells to further understand the biology of senescent cells in aging.Xu Ming...
Cre, enabling us to examinep21Cip1-highly expressing (p21high) cells, a previously unexplored cell population exhibiting several characteristics typical of senescent cells. By crossingp21-Cre mice with different floxed mice, we managed to monitor, sort, image, eliminate or modulatep21highcells in ...
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Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre–loxP system. Cancer Lett 2003 ; 193:183-8; PMID: 12706876 ; http://dx.doi.org/ 10.1016/S0304-3835(03)00007-7A. Ito, M. Asamoto, N. Hokaiwado, T. Shirai, Regulation of cell ...