总之,该文通过构建p21-Cre转基因小鼠模型,提供了一种在体研究p21high细胞生物学特性及作用的有力手段。该模型可以与多种floxed小鼠模型杂交,继而实现在小鼠体内追踪、调节和消除p21high细胞,有助于深入挖掘p21high细胞在自然衰老和各种衰老...
By crossing p21-Cre mice with different floxed mice, we managed to monitor, sort, image, eliminate or modulate p21high cells in vivo. We showed that p21high cells can be induced by various conditions, and percentages of p21high cells varied from 1.5% to 10% across different tissues in 23...
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AIto A, Asamoto M, Hokaiwado N, Shirai T: Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre--loxP system. Cancer Lett 2003, 193: 183–188.AIto A, Asamoto M, Hokaiwado N, Shirai T: Regulation of cell proliferation by induction ...
Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre–loxP system. Cancer Lett 2003 ; 193:183-8; PMID: 12706876 ; http://dx.doi.org/ 10.1016/S0304-3835(03)00007-7A. Ito, M. Asamoto, N. Hokaiwado, T. Shirai, Regulation of cell ...