Mice, Mutant StrainsLangerhans CellsEndosomesDermatitis, ContactProteinsAntigens, CD11cReceptors, Transforming Growth Factor betaHomeostasisImmunophenotypingLangerhans cells (LCs), a sub-population of dendritic cells (DCs) in the skin, participate in the regulation of immunity and peripheral tolerance. The ...
银欣的那把sf140用过一段时间，装在机箱里体验并不好 风切声很大，而且动平衡很烂 ...
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 2001;413:86–91. 18 Sano T, Hikino T, Xue Q, et al. Immunohistochemical inactivation of p14ARF concomitant with MDM2 overexpression inversely correlates with p53 over- expression in oral squamous cell carcinoma...
Focuses on the discovery that more than a quarter of melanoma-prone people worldwide carry germline mutations in CDKN2A, a tumor-suppressor gene. Topic of the use of mice to study the molecular contributions to this cancer; Topic of the genetic aspects of melanoma susceptibility in mice; Questio...
Constitutive p14 knockout mice die early in embryogenesis. A keratinocyte-specific conditional knockout model has shed light on the role of p14 for cell cycle control [74]. Depletion of p14 in hematopoietic lineages will help to understand the role of p14 in hematopoiesis. View article Role of...
The VSV/FAST recombinant consistently generated higher titers of virus in the brains of BALB/c mice after intranasal or intravenous infection compared to the parental VSV/green fluorescent protein (GFP) strain that expresses GFP in place of p14. The VSV/FAST recombinant also resulted in an ...
The status of the gene alterations did not correlate with tumorigenicity in immunocompromized mice or any clinical parameters. Although the mutation rate was higher in glioma cell lines than that reported for glioma tissues, the alterations were molecularly representative of those found in adult de ...
Gene Expression RegulationMice, TransgenicEnhancer Elements, GeneticDeoxyribonuclease IDahlgren L, Willander A.doi:10.1073/pnas.89.9.3899L B ShapiroProc Natl Acad Sci U S AProceedings of the National Academy of Sciences of the United States of America...
In an A549 xenograft nude mouse model, AdFAST did not induce tumor cell fusion or promote mouse survival compared to control mice. In murine 4T1 mammary carcinoma cells, FAST protein expression had modest effects on cell fusion and metabolic activity in vitro. When AdFAST was administered ...
(Raveh et al. 2001) p14ARF (p19Arf in mice) is one of the two genes encoded by the INK4A/ARF locus at chromosome 9p21. (Sherr et al. 2001) Alternative first exons (1a and exon 1b), under the control of different promoters, specify the 5¢ ends of p16INK4A and p14ARF ...