Membrane transporter proteins are essential for the maintenance of cellular ion homeostasis. In the secretory pathway, the P-type ATPase family of transporters is found in every compartment and the plasma membrane. Here, we report the identification of COD1/SPF1 (control of HMG-CoA reductase degra...
Such a rather unusual prokaryotic P-type ATPase is the KdpFABC complex of the enterobacterium Escherichia coli, which serves as a highly specific K(+) transporter. A unique feature of this member of P-type ATPases is that catalytic activity and substrate transport are located on two ...
Such a rather unusal prokaryotic P-type ATPase is the KdpFABC complex of the enterobacterium Escherichia coli, which serves as a highly specific K+ transporter. A unique feature of this member of P-type ATPases is that catalytic activity and substrate transport are located on two different ...
(SA)], associated with phosphatase activity, were located between TMS 2 and 3 in the actuator domain; the sequence of motif 4, which determines ion specificity, can be [PEG(LM)] or [(CSA)PCA(LV)], which was located at the end of the fourth TMS; the phosphorylation site [DKTGTLT] ...
To better understand the molecular determinants that govern P1B-1-ATPase activity in cells, we here report structures of a plant Cu+-ATPase, which combined with functional data and in silico analysis, shed critical light on the molecular function of these cellular pumps. ...
Using an in vitro cell-free assay, we demonstrate that KAE609 directly inhibits ScPma1p ATPase activity. KAE609 also increases cytoplasmic hydrogen ion concentrations in yeast cells. Computer docking into a ScPma1p homology model identifies a binding mode that supports genetic resistance determinants ...
ATP7B, the Wilson disease-associated Cu(I)-transporter, and ZntA from Escherichia coli are soft metal P1-type ATPases with mutually exclusive metal ion sub... ZJ Hou,S Narindrasorasak,B Bhushan,... - 《Journal of Biological Chemistry》 被引量: 0发表: 2001年 Zinc(II) tolerance in Esche...
Accordingly, cells defective in ( 螖 ) accumulate more Ca compared with WT cells, while the Ca -dependent ATPase activity is significantly lower in the mutant cells. Interestingly, the deletion of in impairs the tolerance of the bacteria to oxidative and nitrosative stress. Overall, our results ...
The least investigated members of the P-type superfamily of primary active pumps belong to the type IV and V subfamilies, which are unique to eukaryotic organisms. Although accumulating data indicates a central role for these transporters in the secretor
(1) A member of the transmembrane 9 superfamily of proteins, TM9SF2 (663aa), that may function as an endosomal ion channel or small molecule transporter. (2) Phospholipase B domain-containing protein 2 (589aa) that may function as a phospholipase. (3) Protein p76 IgBP (874aa), a cle...