Metal interactions with the transmembrane region of HupE Ni2+ transporter explain its efficiencyRowińska-ŻyrekMagdalenaJOURNAL OF INORGANIC BIOCHEMISTRY
The H+ -coupled divalent metal-ion transporter DMT1 serves as both the primary entry point for iron into the body (intestinal brush-border uptake) and the route by which transferrin-associated iron is mobilized from endosomes to cytosol in erythroid precursors and other cells. Elucidating the mol...
copper (Cu2+), zinc (Zn2+), sodium (Na+), potassium (K+), etc. Under normal circumstances, the concentration of metal ions is maintained dynamic balance under the regulation of various transporter proteins and storage libraries. But when subjected to radiation, tumors, or accidental injuries...
Conservative and nonconservative mutations of the transmembrane CPC motif in ZntA: effect on metal selectivity and activity. ZntA from Escherichia coli belongs to the P1B-ATPase transporter family and mediates resistance to toxic levels of selected divalent metal ions. P1B-type A... SJ Dutta,J Liu...
a specialised zinc chelator able to catch the metal from the colonized environment and transfer it to an appropriate target protein (most often a transmembrane transporter) [20,21]. In many bacteria, the extracellular component of zinc specific ABC transporters can cooperate with an additional protei...
As an essential trace element, copper is obtained mainly through the digestion of food, followed by absorption in the intestines, and transport into cells by DMT1 and transmembrane copper transporter 1 (Fig.3) [129]. Based on the electron configuration of transition metals, cytosolic copper forms...
transition metal ion fluorescence resonance energy transfer (tmFRET), as a highly sensitive method for direct measurements of conformational changes in response to K þ and show that K þ inhibits Na þ and substrate binding possibly by binding an outward-closed conformation of the transporter....
ABCG transporter proteins with beneficial activity on plants Anindita Dhara, Ayan Raichaudhuri, in Phytochemistry, 2021 1.3 Cellular detoxification and heavy metal resistance Heavy metals are those elements that fall under the d-block of elements in the periodic table; these heavy metals have a d...
et al. Cloning and characterization of a mammalian proton- coupled metal-ion transporter. Nature 388, 482–488 (1997). 39. Preza, G. C. et al. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload....
The essential amino acid residues that form the prox- imal and distal heavy-metal-binding sites have been iden- tified for the CH34T zinc-specific RND HME3a transmembrane transporter ZneA [64]. Using the ZneA protein as a backbone, we aligned the eight STM 6070 RND transmembrane proteins ...