Expression of the ABC transporter P-glycoprotein (P-gp or ABCB1) is associated with resistance to chemotherapy in cancer. However, early investigations into the regulation of ABCB1 expression revealed that the process is not a classical induction as observed for certain metabolizing enzymes. The ...
ABC20, PGY1;CD243;PGP, P-GP, Multidrug resistance protein 1, MDR1, ATP-binding cassette transporter subfamily B member 1, ABCB1, Permeability glycoprotein, Cluster of differentiation 243 Definition P-glycoprotein (PGP) is a member of the adenosine triphosphate binding cassette (ABC) transporter ...
IMPORTANCE OF THE FIELD: P-glycoprotein (P-gp) is the most characterized drug transporter in terms of its clinical relevance for pharmacokinetic disposition and interaction with other medicines. Clinically significant P-gp related drug interactions appear restricted to digoxin. P-gp may act as a ...
Multidrug transporter is a closely related family (ABC transporters) of an integral membrane glycoprotein that exports a variety of solutes from the cytoplasm and these are mostly involved in drug efflux and influx (Williamson, 2006). From: Journal of Ethnopharmacology, 2012 ...
人P-gp是由多药耐药基因MDR1编码,属于ATP结合盒转运蛋白超家族中B家族(ATP-binding cassette transporter,sub-family B,member 1)的一个成员,因此又称ABCB1[3-5]。该基因定位于第7号染色体长臂2区1带(7q21)上,全长约209 Kb,共含有29个外显子,编码的蛋白全长包含有1 280个氨基酸,分子量大小约为170 kD,...
Mechanism of activity of PXR enhancing expression of efflux transporter in the various parts of the body. (Color figure Online) Full size image Pregnane X Receptor and ABC transporters in Alzheimer’s disease Over the last decade, researchers have been trying to establish the role of ABC transpor...
P-glycoprotein is a membrane-binding protein, belonging to the transporter ATP-binding material (ATP-binding cassette transporters,ABCT) member of the superfamily, 翻译结果4复制译文编辑译文朗读译文返回顶部 P sugar protein is a membrane protein, protein ATP combined with property belonging to trans-bin...
In certain situations, such as chemotherapy to the periphery, it might be advantageous to upregulate ABC transporter expression to increase CNS protection; we should devise strategies to do this in a safe manner. Second, ABC transporter expression in other barrier and excretory tissues seems to be...
P-glycoprotein (Pgp) is an ABC transporter responsible for the ATP-dependent efflux of chemotherapeutic compounds from multidrug resistant cancer cells. Better understanding of the molecular mechanism of Pgp-mediated transport could promote rational drug
Imre J. Holb3,4, Lóránt Székvölgyi5, Gábor Szabó1, László Csanády6, Gergely Szakács2,7,† & Katalin Goda1,† P-glycoprotein (Pgp) is an ABC transporter responsible for the ATP-dependent efflux of chemotherapeutic compounds from multidrug resistant cancer cells....