The multidrug transporter P-glycoprotein: a mediator of melanoma invasion? J Invest Dermatol. 2008; 128 :957–971. [ PubMed ]Colone M, Calcabrini A, Toccacieli L, Bozzuto G, Stringaro A, et al. (2008) the multidrug transporter P-glycoprotein: a mediator of melanoma invasion . J Invest...
外排转运体P-gp预测模块介绍 外排转运体(efflux transporter)属于ABC家族,能够促进化合物从胞内排除。p-糖蛋白(P-glycoprotein,P-gp)是药物发现中最为熟知的外排转运体,可从多种细胞中排出化合物。其功能与药物的吸收、分布、排泄、中枢神经系统作用、多药耐药(MDR)有...
参与药物转运的ABC转运体主要包括P糖蛋白(P-glycoprotein,P-gp)、乳腺癌耐药蛋白(breast cancer resistance protein,BCRP)、多药耐药相关蛋白(multidrug resistance protein,MRP)等。 图1 药物转运蛋白在人体各组织器官中的分布 各国指导原则对转运体研究的要求 药物转运体是决定细胞内药物积累的关键因素,其活性往往与药...
P-glycoprotein(P-gp) is a membrane transporter pump that leads to efflux ofanticancer drugsfrom tumor cells, as shown inFig. 2. Overexpression of p-glycoprotein is one of the major mechanisms involved inmultidrug resistance(MDR). Over the past years, significant efforts have been made toward ...
4. Gottesman, M.M. and V. Ling, The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett, 2006. 580(4): p. 998-1009. 5. Cole, S.P., et al., Overexpression of a transporter g...
参与药物转运的ABC转运体主要包括P糖蛋白(P-glycoprotein,P-gp)、乳腺癌耐药蛋白(breast cancer resistance protein,BCRP)、多药耐药相关蛋白(multidrug resistance protein,MRP)等。 图1 药物转运蛋白在人体各组织器官中的分布 各国指导原则对转运体研究的要求...
PROTEIN 001,P-gp,P-Glycoprotein [Chemical/Ingredient],p-glycoprotein,p glycoprotein,p-gp,glycoprotein p,ATP-Binding Cassette, Sub-Family B, Member 1,Multidrug Resistance Protein 1,PGY 1 Protein,PGY-1 Protein,P-glycoprotein,P-Glycoprotein 1,ABCB1,Multidrug Resistance 1,P-Glycoprotein Transporter ...
P-gp(P-glycoprotein,P-gp)是1976年由Juliano等[1]在中国仓鼠卵巢癌耐药细胞中发现的一种跨膜蛋白,是第一个被发现能够介导肿瘤细胞多药耐药的蛋白,也是目前公认与癌细胞多药耐药关系最为密切的蛋白[1-2]。最近的一系列研究表明:除了介导癌细胞多药耐药以外,P-gp类蛋白还能够以依赖于或非依赖于其药物泵的功能...
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While many factors could cause drug resistance, one of the most popular reasons is because a protein transporter that expels drugs out of cells, thereby preventing the benefits of treatment. The protein transporter on cell membrane is known as P-glycoprotein. ...