(cAMP)-resistant mutants of the Chinese hamster ovary and the mouse adrenal cortical carcinoma cells harboring defective regulatory (RI alpha) subunits of the cAMP-dependent protein kinase (PKA) are more sensitive than wild-type cells to chemotherapeutic agents that are substrates for P-glycoprotein....
1981 . 31 P NMR of enzyme-bound substrates of rabbit muscle creatine kinase. Equilibrium constants, interconversion rates, and NMR parameters of enzyme-... B Rao - 《Journal of Biological Chemistry》 被引量: 9发表: 1981年 Cationic binuclear \"A-frame\" complexes of rhodium(I) and iridium(...
p-PKA IIα reg (Ser 96) has been discontinued and replaced byp-PKA IIα reg (C-5): sc-377575. 関連項目 ChemCruz™ ChemicalPKA Inhibitors,PKA ActivatorsorPKA Substrates可用于PKA细胞反应的功能性分析 订购信息 p-PKA IIα reg (C-5): sc-377575 [用于替代p-PKA IIα reg (Ser 96)的推...
pKa < 8 (acids and neutrals) . Examples of P-gp efflux substrates include calcium channel blockers such as nifedipine(3), cyclosporin, erythromycin, loperamide, talinolol, protease inhibitors such as HIV protease inhibitor ritonavi...
Spatiotemporal specificity of cAMP action is best explained by targeting protein kinase A (PKA) to its substrates by A-Kinase Anchoring Proteins (AKAPs). A... R Efendiev,Bret K Samelson,Bao T Nguyen,... - 《Journal of Biological Chemistry》 被引量: 149发表: 2010年 ...
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases Protein-Serine-Threonine KinasesMitogen-Activated Protein KinasesIntracellular Signaling Peptides and ProteinsGene Expression RegulationEnzyme Activation... M Cargnello,PP Roux - 《Microbiology & Molecular Biology ...
pKa < 8 (acids and neutrals). ——表明这种化合物更可能不是P-gp外排底物。 P-gp外排底物的实例包括钙通道阻滞剂,如硝苯地平(3); 以及环孢素、红霉素、洛哌丁胺、塔利诺尔、蛋白酶抑制剂,如HIV蛋白酶抑制剂利托那韦(4); 还有因子Xa抑制剂阿哌沙班(5)、酪氨酸激酶抑制剂,如达沙替尼(6)和他克莫司。
1.1.77, 227aa) that catalyses the methyl esterification of the free alpha-carboxyl group of abnormal L-isoaspartyl residues, which occur spontaneously in protein and peptide substrates as a consequence of molecular ageing. pCMV Usually part of the name of an expression vector that contains the ...
31P NMR signals from substrates and products of alkaline phosphatase have been adapted to measure the rates and product ratios for the hydrolysis and phosphotransferase reactions from pH 6 to 10. Below pH 8, glycerol is a poorer acceptor than H2O (glycerol phosphates:Pi = 0.5). Tris is a mo...
pKa > 4. In contrast, a compound is more likely to be a non-P-gp efflux substrate if its: N + O ≤ 8; MW > 400; and pKa < 8 (acids and neutrals) . Examples of P-gp efflux substrates include calcium channel blockers such as nifedipine(3), cyclosporin, erythromycin, loperamide,...