pKa < 8 (acids and neutrals) . Examples of P-gp efflux substrates include calcium channel blockers such as nifedipine(3), cyclosporin, erythromycin, loperamide, talinolol, protease inhibitors such as HIV protease inhibitor ritonavi...
近期研究在心血管疾病模型中发现,PKA 对 Kemptide Phospho - Ser5 的磷酸化水平与心肌细胞的收缩功能密切相关。通过调节 PKA 活性改变 Kemptide Phospho - Ser5 的磷酸化程度,能够影响心肌细胞内钙离子的转运和心肌收缩蛋白的活性,为治疗心血管疾病提供了新的潜在靶点和研究方向。在神经系统疾病研究中,也观察到 PKA...
pKa < 8 (acids and neutrals) . Examples of P-gp efflux substrates include calcium channel blockers such as nifedipine(3), cyclosporin, erythromycin, loperamide, talinolol, protease inhibitors such as HIV protease inhibitor ritonavir(4), factor Xa inhibitor apixaban(5), tyrosine kinase inhibitors ...
1.1.77, 227aa) that catalyses the methyl esterification of the free alpha-carboxyl group of abnormal L-isoaspartyl residues, which occur spontaneously in protein and peptide substrates as a consequence of molecular ageing. pCMV Usually part of the name of an expression vector that contains the ...
Dhh1/DDX6 belong to the DEAD-box family ofRNA helicases, which bind RNA when ATP bound and release RNA substrates upon ATPhydrolysis(Fig. 13.1). DDX6 isessential for P-body assembly in human HeLa cells andinduced pluripotent stem celllines (Ayache et al., 2015;Di Stefano et al., 2019...
Kemptide is a phosphate acceptor peptide that serves as a synthetic substrate for PKA (Km = 16 µM). The corresponding fluorescent and biotinylated peptides are also proven to be good substrates for PKA. Detailed Information Material Safety Data Sheets (MSDS) Storage -20°C References Ref: Pf...
However, it has not been determined how PKA signaling leads to changes in motility, and specific proteins responsible for these changes have not yet been identified as PKA substrates. Anti-phospho-(Ser/Thr) PKA substrate antibodies detected a sperm protein with a relative molecular weight of 270...
2.5 pKa 9.06±0.50(Predicted) 2.6 Water Solubility ≥ 17.1mg/mL in DMSO 2.7 StorageTemp Keep in dark place,Inert atmosphere,Store in freezer, under -20°C3. Use and Manufacturing3.1 Description TAME is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20...
1065 Akt Substrates-1 Biotinylated Peptide Biotinylated Peptide 1.25 ml CNY 1,944 1071 Akt Substrates-3 Biotinylated Peptide Biotinylated Peptide 1.25 ml CNY 1,944 1075 NMDAR1 (Ser897) Biotinylated Peptide Biotinylated Peptide 1.25 ml CNY 1,944 1077 Akt Substrates-2 Biotinylated Peptide Biotinylated ...
each consisting of six membrane spanning domains followed by a cytoplasmic domain which includes a nucleotide binding fold. The P-glycoprotein is a member of a large superfamily of transport proteins which utilize ATP to translocate a wide range of substrates across biological membranes. This superfami...