接下来,为了阐明七氟烷加速认知能力下降的潜在机制,作者通过转染APP的N2a细胞进行体外实验,测量了线粒体损伤和功能的变化。结果表明,七氟烷暴露可能通过促进 p-Drp1 S616介导的线粒体裂变加速线粒体损伤和功能障碍。 5. 七氟烷主要调节 N2a/APP 细胞的代谢表型 随后作者通过检测 ECAR 和 OCR 进一步研究了七氟烷暴...
接下来,为了阐明七氟烷加速认知能力下降的潜在机制,作者通过转染APP的N2a细胞进行体外实验,测量了线粒体损伤和功能的变化。结果表明,七氟烷暴露可能通过促进 p-Drp1 S616介导的线粒体裂变加速线粒体损伤和功能障碍。 5. 七氟烷主要调节 N2a/APP 细胞的代谢表型 随后作者通过检测 ECAR 和 OCR 进一步研究了七氟烷暴...
Department of Anesthesiology, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), No. 1017, Dongmen North Road, Shenzhen, 518020, ChinaYanmei ...
Immunoblots revealed decreased DRP1 phosphorylation at S637 (a fission inhibiting site) with no major change in total DRP1, S616 phospho-DRP1, MFN1/2 or OPA1 levels in AMPK-KD. High resolution optical mapping of ex vivo perfused hearts uncovered marked (by 39.5%, p<0.001) conduction slowing...
FTY720-P; mitochondria; TFAM; STAT3; DRP1 S616; cardiomyocytes; metabolism; S1PR; ATP; nucleoids1. Introduction FTY720 is an immunosuppressant currently used for the treatment of relapsing–remitting multiple sclerosis [1]. The phosphorylated form of this compound interacts with sphingosine-1-...