p-AKT(T308) pAb 现货抗体,性能参数:一抗能做WB,IHC,IF等实验,1:500-1:1000左右稀释。说明书在www.bioworlde.com下载!Bioworld再推三大精品现货内参:GAPDH,β-Actin, Tub
The expression level of Akt and p-Akt-Thr308 in group B was signifcantly lower than in group A (Akt 0.41 ± 0.16 vs 1.12 ± 0.77, P = 0.008; p-Akt-Thr308 0.47 ± 0.19 vs 0.82 ± 0.45, P = 0.036) and the control group (Akt 0.41 ± 0.16 vs 1.03 ± 0.53, P = 0.018; p-...
AKT一般被认为是在质膜上被激活 激活后进胞浆或者入核 首先PDK-1磷酸化AKT的T308位点,此时AKT活性极大增加 但还没有完全活化 需mTOR磷酸化s473位点 s473位点破坏了AKT的疏水性 以上两者使AKT活性充分激活 行使完功能后 T308和S473再被去练酸化 终止AKT信号 检测肯定是两者都检测最好 结果如果只有一个点有差异...
The following antibodies were employed: VCP (#2648), GFP (#2555), p-eIF2α (#9721), eIF2α (#9722), CHOP (#2895), Nrf1(#8052), p-ERK1/2 (#9101), ERK (#9102), p-Akt (S473) (#9271), Akt (#9272), p-Akt (T308) (#9275), p-p70S6K (#9234), p70S6K (#2708), p...
p37 delta-Protein levels but not p110 delta levels correlated with increased pAKT(T308) and pERK levels. The p37 delta-mRNA levels did not correlate with the protein levels, indicating major regulation at the translational/protein level. Deregulation of signaling pathways is a hallmark of cancer...
We found high levels of p-Akt/PKB correlating to aggressive disease and p-Akt/PKB (T308) showed inverse correlation to PTEN levels. The regulatory isomers p55alpha/p50alpha showed higher levels in favorable neuroblastoma as compared with aggressive neuroblastoma. The PI3K-subunit p110alpha was fou...
P—PI3K—P110 定位于细胞浆和细胞膜 ,P— AKT—T308定位于细胞浆和细胞核。在高倍镜下取4 个不同的视野,各计数200个细胞,计算 阳性细胞的百 分比:0分为阴性,1分为 阳性细胞数 ≤10%,2分为 11%～50%,3分为51% ～75%,4分为 75%;按染色 强度记分 :0分为无色,1分为浅黄色 ,2分为棕黄色,3...
0.7 μM剂量的A66治疗,通过高度转化p85α iSH2突变体KS459delN,DKRMN-S560del,和K379E,并通过所有p85突变体减少Akt对T308的磷酸化作用,从而使集落形成减少75-80%。 体内研究 单剂量100mg / kg的A66,在体外SK-OV-3肿瘤组织中,给药1小时和6小时后,使Akt/PKB 和p70 S6激酶的磷酸化显著减少,但是对ERK没...
[1]0.7 μM剂量的A66治疗,通过高度转化p85α iSH2突变体KS459delN,DKRMN-S560del,和K379E,并通过所有p85突变体减少Akt对T308的磷酸化作用,从而使集落形成减少75-80%。[2] 体内研究 单剂量100mg / kg的A66,在体外SK-OV-3肿瘤组织中,给药1小时和6小时后,使Akt/PKB 和p70 S6激酶的磷酸化显著减少,但是...
This trend was seen in phospho-T308 Akt but not phospho-S473, most likely because mTOR is the kinase that phosphorylates S473 in these cells (Sarbassov et al., 2005). Tolerance to Mutation in the p110α Affinity Pocket In order to determine how tolerant each p110α affinity pocket ...