司美格鲁肽是一种长效胰高血糖素样肽1受体激动剂(GLP-1RA),多项临床研究和回顾研究的结果表明,GLP-1RA受试者减掉的体重中或有近40%为主要由肌肉质量构成的瘦体重(Lean Body Mass),而肌肉流失会增加患心血管、骨质疏松症等疾病的风险。 副作用显现,是在为本土的司美格鲁肽仿制药企及创新减重药研发赛道的厂商提...
而在两款药物巨大的成功之下,仍有能成功突围的机会在隐现。 此前司美格鲁肽的STEP1研究和SUSTAIN8研究表明,入组患者减轻的体重约40%是瘦体重(Lean body mass),而这会导致机体免疫力下降从而增加感染风险等一系列不良事件。 因而需要开发更优的疗法,以求在减肥和保护肌肉之间找到平衡。 目前,各大药企和市场对于这...
These include consistent self-monitoring, like weigh-ins; maintaining a balanced diet; exercises to help build lean body mass; and lifestyle programming to create a structured approach. Whether you choose to use a weight-loss medication or not, safety should be front and center to your approach...
Rapidly dropping pounds is associated with a loss of muscle mass and other undesirable effects—including looking older.
When the researchers tested the effect of BRP on lean mice and minipigs (which more closely mirror human metabolism and eating patterns than mice do) they found that an intramuscular injection of BRP prior to feeding reduced food intake over the next hour by up to 50% in both animal models...
Keeping an eye on what you eat while taking Ozempiccan boost its weight-loss effectiveness and help manage side effects. Prioritize lean protein, and incorporate high-fiber carbohydrates and healthy fats to maintain muscle mass and keep your blood sugar steady. Also, steer clear of highly processe...
But researchers noticed something else: The patients lost body fat. In 2017, Novartis decided to run one more trial in people with obesity and diabetes. It found the drug caused an average loss of 21% in fat mass and also a 4% gain in lean mass — a combination that had not been ...
Reference: “Semaglutide Reduces Cardiomyocyte Size and Cardiac Mass in Lean and Obese Mice” by Matthew D. Martens, Yasser Abuetabh, Mya A. Schmidt, Matthieu C.P. Zolondek, Heidi L. Silver, Jody L. Levasseur, Mourad Ferdaoussi and Jason R.B. Dyck, 16 October 2024,JACC: Basic to ...
The future of obesity medicine is all about developing compounds or combining compounds that hit multiple receptors in the body related to appetite and potentially even metabolic rate, nutrient partitioning (how your body selects which fuels it puts in storage), and lean muscle mass retention. ...
Peralta-Reich. Fueling it with healthy and nutritious options like lean proteins, fruits, vegetables, and good carbohydrates, while avoiding high-fat and processed foods, is ideal. FYI: Eating enough protein in particular is super important for ensuring you maintain your muscle while on Ozempic....