Components of the 2-oxoglutarate dehydrogenase complex also catalyze carboligase reaction or reaction with molecular oxygen, which are of potential physiological significance.doi:10.1016/B978-0-12-819460-7.00127-4Victoria BunikTristan WagnerMarco Bellinzoni...
to be an order of magnitude longer, contributed by theprotein domainsand their linkers shown inFig. 1. The arm length of about 100 Å is required to enable the protein-bound lipoyl group to cover the distance between the active sites of a “classic” 2-oxoglutarate dehydrogenase complex....
The 2-oxoglutarate dehydrogenase complex (OGDHc) orchestrates a critical reaction regulating the TCA cycle. Although the structure of each OGDHc subunit has been solved, the architecture of the intact complex and inter-subunit interactions still remain unknown. Here we report the assembly of native,...
Actinobacteria possess unique ways to regulate the oxoglutarate metabolic node. Contrary to most organisms in which three enzymes compose the 2-oxoglutarate dehydrogenase complex (ODH), actinobacteria rely on a two-in-one protein (OdhA) in which both the oxidative decarboxylation and succinyl transferase...
The nucleotide sequence of the gene encoding the 2-oxoglutarate dehydrogenase component (E1o) of the 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii has been determined. The protein-coding sequence consists of 2832 bp (944 codons, including the AUG start codon and the UAA stop codon...
Mitochondrial 2-oxoglutarate (α-ketoglutarate) dehydrogenase complex (OGDHC), a key regulatory point of tricarboxylic acid (TCA) cycle, plays vital roles in multiple pathways of energy metabolism and biosynthesis. The catalytic mechanism and allosteric
et al. The alpha-ketoglutarate dehydrogenase complex in cancer metabolic plasticity. Cancer & metabolism 5, 3, https://doi.org/10.1186/s40170-017-0165-0 (2017). Article Google Scholar Xu, T. et al. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. Nature...
作者:Dagda Tanner Mattheus 页数:252 ISBN:9786139196456 豆瓣评分 目前无人评价 评价: 写笔记 写书评 加入购书单 分享到 推荐 我要写书评 Oxoglutarate Dehydrogenase Complex的书评 ···(全部 0 条) + 加入购书单 谁读这本书?··· 二手市场· ·...
Oxoglutarate Dehydrogenase is an enzyme involved in the oxidative decarboxylation of α-ketoglutarate to Succinyl-CoA within the α-ketoglutarate dehydrogenase complex. It plays a crucial role in energy production and metabolism. AI generated definition based on: Medical Biochemistry (Fourth Edition), 2002...
Likewise, high glutamate dehydrogenase activity, reduction in 2-oxoglutarate dehydrogenase complex (ODHC), and glutamate efflux attribute to overproduction. Under the high ammonium concentrations favoring glutamic acid synthesis, glutamate dehydrogenase (GDH) catalyzes ammonia assimilation of 2-oxoglutarate to...