Figure 1. The MinION sequencing device DNA sequencing is performed by adding the sample to the flowcell. When DNA molecules pass through or near the nanopore, there will be a change in the magnitude of the current in the nanopore, which is measured by a sensor. The data streams are passed...
Nanopore sequencing works on the principle that as nucleic acid molecules pass through a nanopore channel in a membrane that separates two electrolyte-filled chambers, it disrupts the current and produces a characteristic electrical signal.The chamber where sequencing occurs is called the cis side, whi...
Long-read Oxford Nanopore sequencing has democratized microbial genome sequencing and enables the recovery of highly contiguous microbial genomes from isolates or metagenomes. However, to obtain near-finished genomes it has been necessary to include shor
Nanopore sequencing was instrumental, along with other sequencing technologies, in completing the remaining 8% of the human genome which had been inaccessible for decades. These regions are highly-repetitive and would have been impossible to resolve without Oxford Nanopore Technologies' ultra-long sequenc...
NEW YORK – Researchers from the University of Washington have developed a new approach that promises to achieve long-range, single-molecule sequencing of intact protein strands using the commercially available platform from Oxford Nanopore Technologies. Described in a BioRxiv preprint...
In February2012at the AGBT conference, Oxford Nanopore presented the first ever nanopore sequencing data, and provided an overview of the hardware and software behind the GridION and MinION systems. These data included small genomes that had been seq...
Nanopore‐based sequencing is scalable, portable, and theoretically capable of sequencing the entire mitochondrial genome in a single contig. Furthermore, the recent development of a nanopore protein with dual reader heads allows for clear identification of nucleotides within homopolymeric stretches, ...
Intellectual property Oxford Nanopore has a broad patent portfolio, through in-house development and licensing agreements with third parties. Oxford Nanopore has an intellectual property portfolio of more than 2,600 issued patents and patent applications
and also non-biological analytes. Oxford Nanopore has developed and currently commercialises a high-performance DNA/RNA sequencing technology based on engineered protein nanopores, which are at the core of Oxford Nanopore’s ambitious product development pipeline and scaling ambitions for the coming...
1). The FASTQ file generated by the nanopore whole-genome sequencing consortium was used for the alignment process. The reported and the calculated depth of coverage was found to be ~ 30X. Then, it was down-sampled to 20X and 10X coverage only. The SV call set is used as a ...