There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to AEDs, such as TRILEPTAL, during pregnancy. Encourage women who are taking TRILEPTAL during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling 1-888-233-2334 or...
There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to AEDs, such as oxcarbazepine, during pregnancy. Encourage women who are taking oxcarbazepine during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling 1-888-233-...
Two women were treated with oxcarbazepine during pregnancy and lactation. Milk levels of the 10-hydroxy-oxcarbazepine metabolite in breastmilk were 50 to 65% of the maternal blood level in one mother during the first week postpartum. In the second mother, milk levels were 70 to 80% of matern...
side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition[1]. Oxcarbazepine was approved for use as an anticonvulsant in Denmark in 1990, Spain in 1993, Portugal in 1997, and eventually for all other EU countries in 1999. It was approved in the US...
Overnight ‘switch’ from CBZ to OXC (using CBZ:OXC ratio of 1:1.5) has been used for patients responsive to CBZ, but with dose-related side-effects. Owing to individual variations in CBZ enzyme autoinduction, however, overnight switching is advised only for those on CBZ <800 mg daily;...
, and women treated with oxcarbazepine should consider additional contraceptive measures. Due to the absent or lower enzyme-inducing effect of oxcarbazepine, switching from carbamazepine to oxcarbazepine can result in increased serum concentrations of comedication, sometimes associated with adverse effects....
Oxcarbazepine (OXC), a structural analogue of CBZ, was developed in an effort to avoid side effects from CBZ and its active metabolites and obtain a more suitable patient profile. The objective was to improve the tolerability and pharmacokinetic profile of the drug while decreasing its potential ...
side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition[1]. Oxcarbazepine was approved for use as an anticonvulsant in Denmark in 1990, Spain in 1993, Portugal in 1997, and eventually for all other EU countries in 1999. It was approved in the US...
No adequate and well-controlled studies in pregnant women; however, the drug is closely related to carbamazepine, which has been associated with teratogenic effects in humans. Limited data from pregnancy registries suggest that use of oxcarbazepine during pregnancy may be associated with congenital ...