Use oxcarbazepine with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done. Due tophysiologicchanges during pregnancy, plasma levels of the active metabolite of oxcarbazepine, MHD, may gradually...
If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy. Since birth control pills, patches, implants, and injections may not work if taken with this medication (see also ...
The use of TRILEPTAL should be avoided inpatients positive for HLA-B*1502 unless the benefits clearly outweigh the risks. Consideration should also be given to avoid the use of other drugs associated with SJS/TEN in HLA-B*1502 positive patients, when alternative therapies are otherwise equally ...
Oxcarbazepine is an anticonvulsant drug closely related to carbamazepine and is reportedly better tolerated. Oxcarbazepine has been reported to be efficacious in the treatment of neuropathic pain. OBJECTIVES: To determine the benefits and harms of oxcarbazepine for different forms of neuropathic pain. ...
or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy. Since hormonal birth control may not work if taken with this medication (see alsoDrug Interactionssection), discuss reliable forms of birth control with your doctor...
Warning signs and symptoms, alongside risks and benefits must be discussed with patients if this management is chosen. Any patient positive for the above markers and tolerating CBZ without adverse effects for over 3 months is at low risk of hypersensitivity to this AED. In the case of a CBZ ...
Prior to initiating oxcarbazepine therapy, consider screening genetically at-risk populations for HLA-B*1502. Patients who test positive for the allele should not receive oxcarbazepine therapy unless benefits clearly outweigh risks. (See Pharmacogenetic Testing under Dosage and Administration.)...
Oxcarbazepine and its active metabolite, MHD, cross the human placenta and oxcarbazepine is structurally related to carbamazepine, which is a known human teratogen. Do not use during pregnancy unless the benefits outweigh the risks. If a woman inadvertently becomes pregnant while taking oxcarbazepine, ...
The benefits of using CBZ in such settings is supported by results from a study of 19 infants with BFNE, which showed that seizures promptly respond to low-dose oral CBZ. Early diagnosis and treatment with oral CBZ was associated with dramatically shortened hospitalization with no observed side ...
Oxcarbazepine (OXC) is a frequently prescribed antiepileptic drug for managing focal and generalized seizures. Its therapeutic benefits are limited by its dose-dependent side effects. Nose-to-brain delivery is a novel route for improving the efficacy of antiepileptics. Drug encapsulation in mucoadhesive...