OX40: Structure and function - What questions remain? Mol Immunol. 2017;83(13-22.Willoughby J, Griffiths J, Tews I, Cragg MS. OX40: Structure and function - what questions remain? Mol Immunol. 2017;83:13- 22. doi: 10.1016/j.molimm.2017.01.006....
(APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, ...
OX40L 能够在抗原呈递细胞诱导表达，其功能是调控抗原识别导致的T 细胞激活[5]。 受抗原刺激后，OX40 迅速在活化的幼稚CD4+和CD8+T 细胞诱导表达。体内、体外实验均表明活化后最初1 小时内OX40 的表达量比较少，而在受刺激后的24 小时到4-5 天都有可能出现OX40 表达高峰[6]。OX40 功能的行使离不开OX...
Reduced numbers and impaired function of regulatory T cells in peripheral blood of ischemic stroke patients[J]. Mediators Inflamm, 2016,2016:2974605. DOI: 10.1155/2016/2974605 . 返回引文位置Google Scholar 百度学术 万方数据 [5] Willoughby J , Griffiths J , Tews I ,et al. OX40: structure ...
the immune system that includes B7, CD40 Ligand, CD30 Ligand, CD27 Ligand and 4-1BB Ligand. Because OX40 appears as a late activation-induced T cell surface antigen, it has been speculated that the major function of OX40-OX40L interaction is to transmit a late co-stimulatory signal to...
(MurataK,NoseM,NdhlovuLC,SatoT,SugamuraK,IshiiN.ConstitutiveOX40/OX40ligandinteractioninducesautoimmune-likediseases.JImmunol.2002;169:4628–4636和SatoT,IshiiN,MurataK,KikuchiK,NakagawaS,NdhlovuLC,SugamuraK.ConsequencesofOX40-OX40ligandinteractionsinlangerhanscellfunction:enhancedcontacthypersensitivityresponse...
Function Is a costimulatory molecule implicated in long-term T-cell immunity Ligand/Receptor TNFSF4, OX40L, GP34, human herpesvirus 6B/HHV-6B. Bioactivity Measured by its ability to bind OX40L Cell Targets Antigen presenting cells Cell Type B cells, T cells, Th1, Th17, Th2,...
OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.根据您的关注的重组小鼠OX40(TNFRSF4)(C端His标签),rOX40,rmTNFRSF4,...
OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.根据您的关注的重组人OX40(TNFRSF4)(CD134)(C端Fc标签),Recombinant ...
[4] mendel i,shevach e m.activated t cells express the ox40 ligand:requirmentsfor induction and costimulatory function[j].immunology,2006,117(2):196-204. [5] dollery c m,mcewan j r,henney a m.matrix metalloproteases and cardiovascular disease[j].circ res,1995,77(5):863-868. [6] cr...