而经过进一步的对线粒体中的核酸酶的筛选, 研究人员发现FEN1是剪切氧化新合成mtDNA的关键酶, 而与此相反, 如果Ox-mtDNA在线粒体中被OGG1成功修复,就难以被FEN1剪切而释放进细胞质引发炎症。 值得一提的是,这项研究也是第一次提出Ox-...
However, contrary to the expected upregulation of the master regulator BiP/GRP78 under conditions of ER stress, as in the previous reports from this group and other researchers, this study reports the downregulation of BiP/GRP78 in HepG2 cells stably expressing WT- or missense variants of LDLR...
Although the use of HepG2 cells as the model is a major caveat of the study, the findings of this research may be used as the pilot study to expand further investigations in primary hepatocytes or iPSC- derived cellular models. Similar content being viewed by others Endoplasmic reticulum stres...
线粒体内的核酸内切酶FEN1在非凋亡免疫细胞中响应各种PAMP刺激剪切Ox-mtDNA, 随后这些Ox-mtDNA片段穿过线粒体内膜的通透性转换孔(mitochondrial permeability transition pore, MPTP)和外膜的VDAC多聚体毛孔进入细胞质激活NLRP3炎性小体和cGAS-...