线粒体内的核酸内切酶FEN1在非凋亡免疫细胞中响应各种PAMP刺激剪切Ox-mtDNA, 随后这些Ox-mtDNA片段穿过线粒体内膜的通透性转换孔(mitochondrial permeability transition pore, MPTP)和外膜的VDAC多聚体毛孔进入细胞质激活NLRP3炎性小体和cGAS-...
The NLRP3 Neonatal-Onset Multisystem Inflammatory Disease (NOMID) gain of function mutant could bind non-oxidized mtDNA but had higher affinity for Ox-mtDNA compared to WT with an IC50of 8.1nM. NLRP3 lacking the pyrin domain can bind both oxidized and non-oxidized mtDNA. Isolated pyrin domain...
8-OHdG and decreases in mtDNA-encoded polypeptides (Table 4). Similarly, the All rightsreserved. II) exhibited a decrease in the mRNA expression of the genes encoding MnSOD, 6. Lee HC, Wei YH. Mitochondrial biogenesis and mitochondrial DNA doi...
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. Redox Biol. 2022;52:102305. Available from: https://doi.org/10.1016/j.redox.2022.102305 Nass KJ, van den Berg EH, Faber KN, Schreuder TCMA, ...
The accumulation of misfolded proteins, encoded by genetic variants of functional genes leads to Endoplasmic Reticulum (ER) stress, which is a critical consequence in human disorders such as familial hypercholesterolemia, cardiovascular and hepatic disea
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抖音号:BlackstoneN707IP属地:江苏 最新作品发布时间:2024-10-12 01:22 瞳孔到你脊背的距离 私信关注 关注私信 作品7 喜欢 搜索Ta 的作品 视频 日期筛选 10 死感很重 死感很重 15 我们好像有点暧昧了#精神状态belike 我们好像有点暧昧了#精神状态belike 14 死亡不是生命的尽头 死亡不是生命的尽头广告...
线粒体及细胞质中的Ox-mtDNA含量也因mt-OGG1的表达显著降低。因此研究人员开始对Ox-mtDNA从线粒体到细胞质的释放从而激活炎症小体展开进一步机理研究。 研究人员首先通过证明炎症小体激活和细胞凋亡是相互独立事件而排除Bcl-2相关X蛋白(Bcl...
Author Correction: Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activationdoi:10.1038/s42003-023-05019-2Cabral, AngelaCabral, Julia EliseWang, AngelinaZhang, YiyangLiang, HailinNikbakht, DonyaCorona, Leslie...
The most complex clone studied (DS6) was ascertained to have a mitochondrial genome with a tandemly repeated segment of mtDNA 16.5 kilobases in length. The oxi3 locus was dissected by mutagenesis of DS6 with ethidium bromide and selection of new clones having less complex genotypes. Six ...