线粒体内的核酸内切酶FEN1在非凋亡免疫细胞中响应各种PAMP刺激剪切Ox-mtDNA, 随后这些Ox-mtDNA片段穿过线粒体内膜的通透性转换孔(mitochondrial permeability transition pore, MPTP)和外膜的VDAC多聚体毛孔进入细胞质激活NLRP3炎性小体和cGAS-...
The NLRP3 Neonatal-Onset Multisystem Inflammatory Disease (NOMID) gain of function mutant could bind non-oxidized mtDNA but had higher affinity for Ox-mtDNA compared to WT with an IC50of 8.1nM. NLRP3 lacking the pyrin domain can bind both oxidized and non-oxidized mtDNA. Isolated pyrin domain...
2010年,Augustine M K Choig group的研究率先将mtDNA与NLRP3炎性小体激活联系起来【2】。2012年,Moshe Arditi group发现细胞凋亡过程中释放到细胞质内的氧化线粒体DNA(Ox-mtDNA)可与NLRP3炎性小体结合,从而使后者活化【3】。Michael Ka...
Author Correction: Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activationdoi:10.1038/s42003-023-05019-2Cabral, AngelaCabral, Julia EliseWang, AngelinaZhang, YiyangLiang, HailinNikbakht, DonyaCorona, Leslie...