从构成上来看,mRNA疫苗主要分成两个部分,一个是编码抗原的设计序列,另一个是递送mRNA的载体(图4)。由于mRNA较大且带负电,无法通过细胞膜的阴离子脂质双层,同时mRNA会被先天免疫系统的细胞吞噬而被核酸酶降解。因此mRNA的递送载体非常重要,合适的载体能够减少mRNA被非特异性降解,并将其输送到目标位置。目前mRNA疫苗...
Using ELISPOT assay, we compared the immunogenicity of OVA specific peptide and mRNA administration via different injection manners. Furthermore, in vivo tumor model of B16F10-OVA and MC38-OVA have also been established to evaluate the anti-tumor efficacy of peptide and mRNA vaccine. The ...
DOI: 10.1016/j.vaccine.2017.05.067 . 返回引文位置Google Scholar 百度学术 万方数据 [5] Saade F , Honda-Okubo Y , Trec S ,et al. A novel hepatitis B vaccine containing Advax TM, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal ...
随着印度药物管制总局(DCGI)对以上新冠疫苗的批准,印度的疫苗猫已扩展到 Covishield、Covaxin、Sputnik V、Moderna 疫苗(mRNA-1273)、Janssen 疫苗、ZyCoV-D,并允许进口任何外国疫苗。 此外,印度药物管制总局(DCGI) 还认可Cipla(西普拉公司)仿制的抗病毒药物莫努匹韦(Molnupiravir)来治疗轻度至中度 COVID-19。
Apoptosis induction by the Therien and vaccine RA27/3 strains of rubella virus causes depletion of oligodendrocytes from rat neural cell cultures. J Gen Virol. 2002;83:2135–43. Article CAS PubMed Google Scholar Bello-Morales R, Fedetz M, Alcina A, Tabares E, Lopez-Guerrero JA. High ...
Cytokine mRNA expression and activation of relevant signal pathway profiles elicited by different vaccine adjuvants for BMDCs. a, b, c The cytokine (IL-1β, IFN-γ and TNF-α) mRNA expression from BMDCs was analyzed by RT-qPCR. d The changes of p38 MAPK, p-AKT and p-ERK phosphorylation...
Cell Type T lymphocyte Formulation Containing ≥ 1 X 10*6 / vial frozen cells Cell Purity >95% Cell Viability >90% Mycoplasma Testing The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species. ...
通过特别采用程序 (SAR) 打过至少1针科兴的人,可以到任何一家被批准提供科兴疫苗的诊所,接种第二或第三针,11月1日之后可以预约。提供科兴疫苗的诊所名单请参考疫苗网站获得最新信息 (https://www.vaccine.gov.sg/) 。 3.无法接种mRNA疫苗的人群 无法接种mRNA疫苗大多是因为对辉瑞、莫德纳疫苗过敏,部分人群早先已...
通过特别采用程序 (SAR) 打过至少1针科兴的人,可以到任何一家被批准提供科兴疫苗的诊所,接种第二或第三针,11月1日之后可以预约。提供科兴疫苗的诊所名单请参考疫苗网站获得最新信息 (https://www.vaccine.gov.sg/) 。 3.无法接种mRNA疫苗的人群 无法接种mRNA疫苗大多是因为对辉瑞、莫德纳疫苗过敏,部分人群早先已...
Tumor vaccineRadioimmunotherapymRNA vaccinationTumor metastasis and immune evasion present major challenges of cancer treatment. Radiotherapy can overcome immunosuppressive tumor microenvironments. Anecdotal reports suggest abscopal anti-tumor immune responses. This study assesses abscopal effects of radiotherapy in...