Inbred and outbred mouse strains exhibit differential seizure susceptibility. However, few comparisons exist of the ED50 or median behaviorally impairing dose (TD50) of prototype ASDs in these models in inbred C57Bl/6 vs outbred CFmice, both of which are often used for ASD discovery. Methods We...
Inbred and outbred mouse strains exhibit differential seizure susceptibility. However, few comparisons exist of the ED50 or median behaviorally impairing dose (TD50) of prototype ASDs in these models in inbred C57Bl/6 vs outbred CFmice, both of which are often used for ASD discovery. Methods We...
Alexander HUNC Neuroscience CentreTuttleUNC Neuroscience CentreVivek MUNC Neuroscience CentrePhilipUNC Neuroscience CentreElissa JUNC Neuroscience CentreCheslerUNC Neuroscience CentreJeffrey SUNC Neuroscience CentreMogilUNC Neuroscience CentreNature Methods
Zhong S, Dobson C (1996) Heligmosomoides polygyrus: resistance in inbred, outbred, and selected mice. Exp Parasitol 82:122–131Zhong, S. & Dobson, C. (1996) Heligmosomoides polygyrus: resistance in inbred, outbred, and selected mice. Experimental Parasitology 82,122-131....
Most outbred mice exhibit hybrid vigor similar to or exceeding that of F1 hybrids. Compared to inbred mice, they have longer life span, higher disease resistance, higher reproductive performance, and lower neonatal mortality. Outbred mice are particularly suited as stud males or foster mothers in ...
Mice reared selectively as high- and low-immune responders to reinfection with Heligmosomoides polygyrus showed extremes of resistance and susceptibility after infection when compared to inbred BALB/C, DBA/I, CBA, and SJL/J and outbred Quackenbush (Q) mice. The levels of anti- H. polygyrus ...
However, these previous studies used inbred rodent strains, which limited examination of genetically mediated differences in susceptibility to addiction-like behaviors. Furthermore, these studies focused on acute drug treatments and therefore did not explore molecular changes that accompany long-lasting ...
The present work compared inbred (CBA/Ca) and outbred (Swiss white) strains of mice for their capacity to cope with a Neospora caninum infection and to consistently produce tissue cysts. In each experiment Swiss white and CBA/Ca mice were given three different doses of NC-1 tachyzoites. ...
However, few comparisons exist of the ED50 or median behaviorally impairing dose (TD50) of prototype ASDs in these models in inbred C57Bl/6 vs outbred CF-1 mice, both of which are often used for ASD discovery. Methods We defined the strain-related ED50s and TD50s of several ...
Interestingly, in outbred mice both CD4 and CD8 T cells responded equally while in inbred mice CD8 T cells were predominant. Outbred mice had peak responses later and more prolonged than inbred mice. Thus, inbred mice may not be an accurate model for testing immune responses in humans, ...