Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we use Diversity Outbred (DO) mice to directly ...
Diversity Outbred (DO) mice offer the ability to perform high-resolution quantitative trait loci (QTL) mapping on a very genetically diverse background, thus facilitating identification of candidate genes. Here, we studied a population of 636 male DO mice with four weeks of intermittent ethanol ...
The minor satellite CDI is lower in inbred strains (range: 12.1–23.0) than in wild mice (range: 24.8–35.6). At the extremes, mice from the Kazhak population ofM. m. musculushave minor satellite arrays that are nearly 3 times as diverse as those in the inbred strains ZALENDE/EiJ and ...
A multi-tissue full lifespan epigenetic clock for mice. Aging (Albany NY). 2018;10(10):2832–54. https://doi.org/10.18632/aging.101590. Article CAS Google Scholar Bogue MA, Churchill GA, Chesler EJ. Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database. ...
Both classical laboratory inbred mice (e.g., B6J) and outbred mice (e.g., CD-1 stock) have been commonly used to study PTE. However, these mice models of PTE suffer many major limitations. Notably, late spontaneous PTS, the hallmark of PTE, are largely missing or have not been ...
E. et al. Deep learning predicts gene expression as an intermediate data modality to identify susceptibility patterns in Mycobacterium tuberculosis infected Diversity Outbred mice. EBioMedicine 67, 103388 (2021). 12. Jones, A., Gundersen, G. W. & Engelhardt, B. E. Linking histology and ...
Beginning with G4, the families were outbred using a circle breeding design--a male from family 1 was bred to a female from family 2 and so on. At G6, the colony was expanded to 48 families by breeding a male from family 1 to a female from family 17 and so on. At G12, one ...
To implement genetic diversity, Diversity Outbred (DO) mice were crossed with C57BL/6 to generate (C57BL/6xDO)F1 mice that reliably develop B16F0 tumors after subcutaneous inoculation. (C57BL/6xDO)F1 mice (n=142) treated with combined anti-PD1/anti-CTLA-4 on days 3, 6, and 10 after ...
To address this issue, we used Diversity Outbred (DO) mice, whose genome is derived from eight inbred mouse strains that may capture the level of genetic diversity of the outbred human population. To determine the efficacy of the Mt10 vaccine, we established the CVB3 infection...
investigated the role of genetic variability in the skeletal muscle response to disuse in founder strains of diversity outbred (DO) mice. Founder DO mice consist of eight inbred strains of mice, chosen to maximize genetic diversity and that have an extensively sequenced genome. When crossed, they...