Verrotti A, Greco R, Morgese G, Chiarelli F (1999) Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. Int J Clin Lab Res 29:36–40Verrotti, A. (1999) Carnitine deficiency and hyperammonemia in children receiving valproic acid...
Total blood carnitine was lowered with unesterified carnitine being half of the lowest control value. A diagnosis of mild MCAD deficiency (MCADD) was based on rates of 1-14C-octanoate and 9, 10-3H-myristate oxidation and of octanoyl-CoA dehydrogenase being reduced to 25% of control values. ...
Total blood carnitine was lowered with unesterified carnitine being half of the lowest control value. A diagnosis of mild MCAD deficiency (MCADD) was based on rates of 1-14C-octanoate and 9, 10-3H-myristate oxidation and of octanoyl-CoA dehydrogenase being reduced to 25% of control values. ...
Transporters in the SLC22 family may be secondary active, in which case they rely on various sources of energy to mediate active flux of their substrates. Accordingly, we examined the transport mechanism for two isoforms (533 and 552 amino acids) of chimpanzee SLC22A10. At the three pH leve...
most respiratory chain defects are not.When mitochondrial ATP synthesis has been compromised by a mitochondrial defect, secondary lesions may be generated by changes in mitochondrial protein synthesis, activated proteases and phospholipases, increased matrix CoA and resulting carnitine deficiency, decrease ...
Primary and secondary coenzyme Q10 deficiency: The role of therapeutic supplementation. Nutr. Rev. 2013, 71, 180–188. [Google Scholar] [CrossRef] Garcia-Corzo, L.; Luna-Sanchez, M.; Doerrier, C.; Ortiz, F.; Escames, G.; Acuna-Castroviejo, D.; Lopez, L.C. Ubiquinol-10 ameliorates...
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Ovaries from DCIns 250-treated mice had apparently normal primary and secondary follicles but also cystic tertiary follicles, some of which contained an atretic oocyte, strongly resembling those found in human polycystic ovaries (Figure 3B1,B2;Figure 4C). Ovaries of letrozole-treated mice were simil...
While 95% of bile acids are reabsorbed by enterocytes in the ileum and transported back to the liver, the remaining 5% is converted to secondary bile acid by colonic microbial populations, and subsequently reabsorbed into the portal circulation. In this cycle, known as “hepatic circulation”, ...
The increased ROS change cell proliferation and cell differentiation through their character as a secondary messenger in the homeostasis of the cell. However, due to mitochondrial changes or aerobic glycolysis (Warburg effect), increased ROS levels can lead to oxidative stress (OS), which damages ...