The discovery of these genes, along with other work, has provided a deeper understanding of the mechanisms of motor neuron failure in ALS. Areas of particular interest include the role of transactive response DNA-binding protein 43 and other RNA-processing proteins in the development of disease. ...
Gene therapy for amyotrophic lateral sclerosis and other motor neuron diseases. There are several incurable diseases of motor neuron degeneration, including amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, hereditary spa... JM Alisky,BL Davidson - 《Human Gene Therapy》 被引量: 99发表...
The anterior horn cell diseases, with the exception of polio, are progressive degenerative diseases of the motor neurons. These disorders include SMA types I to III in children and familial and sporadic ALS and its variants (PMA, PLS, and PBP), Kennedy's disease, and SMA type IV in adults...
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease or motor neuron disease (MND), is a rapidly progressive and fatal neurological disease. It was first diagnosed in 1874 by French neurologist Jean-Martin Charcot but despite more than 140 years of research, there is still...
ClinicalTrials数据库提供临床试验Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease的登记号NCT00004771,试验分期Phase 2以及申办者National Center for Research Resources (NCRR)的信息,更过关于临床试验的
Amyotrophic lateral sclerosis and other motor neuron disease . 2001... JF Kurtzke - 《Advances in Neurology》 被引量: 172发表: 1991年 Motor neuron diseases and amyotrophic lateral sclerosis: GM1 antibodies and paraproteinemia. In the past five years, a great diversity of motor neuron diseases ...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with selected both upper and lower motor neuron involvement. Although some i... Z Chen,L Ma - 《Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders》 被引量: 173发表: 2010年 Neurophysiological measures in amyotrop...
Neuron 85, 296–302 (2015). Article PubMed PubMed Central CAS Google Scholar Sweeney, M. D., Sagare, A. P. & Zlokovic, B. V. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J. Cereb. Blood Flow Metab. 35, 1055–1068 (2015). ...
Cumings, J.N., Shortman, R.C., and Skrbic, T. 1965. Lipid studies in the blood and brain in multiple sclerosis and motor neuron disease.J. Clin. Pathol.18:641–644. ArticleCASGoogle Scholar Cunnane, S.C., Ho, S.-H., Dore-Duffy, P., Ells, K.R., and Horrobin, D.F. 1989...
Lymphoma, motor neuron diseases, and amyotrophic lateral sclerosis We studied 9 patients with motor neuron disease and lymphoma. The following several observations have not been recognized in the past: (1) Motor neuron syndromes are associated with either Hodgkin's disease or non-Hodgkin's lymphoma...