Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of instances are due to mutations in Cu/Zn superoxide dismutase (SOD1). Since sporadic and familial ALS affects the same neurons with ...
particularly vulnerable to conditions of suboptimal energy supply2. The axonal compartment often degenerates first in diseases affecting long-projection neurons, such as amyotrophic lateral sclerosis (ALS) and hereditary motor and sensory neuropathies (HMSNs) also known as Charcot–Marie–Tooth diseases (...
This form is much less common than ALS or PBP. It can be inherited or sporadic. Progressive muscular atrophy mainly affects your lower motor neurons. Weakness usually starts in your hands and then spreads to other parts of the body. Your muscles get weak and may cramp. This disease can tur...
SummaryBackground Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons that results in progressive weakness and death from r... Aleksey Shatunov and Kin Mok and Stephen Newhouse and Michael E Weale and Bradley Smith and Caroline Vance and Lauren Johnson and Jan H Ve...
The cellular and molecular mechanisms leading to the specific degeneration and death of motor neurons have been extensively examined. While many hypotheses have been proposed, there is a particular focus on the unique size and shape of motor neurons, which are huge cells with extended processes. ...
Case Analysis for Motor Neuron Disease By Bo Cheng, Like Wu, Xiaojuan Wang and Susan Chu Wu Medical Center, Bejing, China The motor neuron diseases (MNDs) are a group of progressive neurological disorders that destroy motor neurons, the cells tha
The contrast between MND and MS in hospital morbidity and mortality confirms that MS among immigrants to Britain is rare in those of Asian and African ethnic origin. 展开 关键词: Humans Motor Neurons Neuromuscular Diseases Multiple Sclerosis Patient Discharge Age Factors Emigration and Immigration ...
H. et al. Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron 34, 715–727 (2002). Article CAS PubMed Google Scholar Stokin, G. B. et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer’s ...
This paper suggests that this syndrome incurs a loss of the neurotransmitter dopamine. A case study is presented that indicates the unusual range of symptoms, including ataxia, and partial relief by L Dopa (Sinemet). 展开 关键词: Motor Neurons Humans Neuromuscular Diseases Manganese Poisoning ...
Polio spinal diagram. The poliovirus affects the motor neurons of the anterior horn cells, or the ventral (front) grey matter section in the spinal column, which control movement of the trunk and limb muscles including the intercostal muscles. Credit: Wikipedia/CC BY-SA 3.0 ...