Osteoarthritis was denoted as M19.9 based on the International Classification of Diseases 10th Revision (ICD-10). Hypertension was defined as the average of three systolic blood pressure measurements ≥ 140 mmHg, the average of three diastolic blood pressure measurements ≥ 90 mmHg, current...
New bone formation in the form of osteophytes • When knee is involved, standing AP x-ray TREATMENT ACUTE GENERAL Rx • Rest, restricted use or weight bearing, and heat • Walking aids such as a cane (often helpful for weight-bearing joints) ...
The aim was to analyze factors associated with the burden of OA, taking the pattern of joint involvement into account. Methods: From a random sample of 8,995 persons with OA (ICD-10 codes M15 [polyarticular], M16 [hip] or M17 [knee]) from a German statutory health insurance, 3,564 ...
To further elucidate the function of UCHL1 in osteoclastogenesis, LysM-Cre;UCHL1fl/flmice (cKO mice) were generated, resulting in diminished UCHL1 expression in all myeloid lineage cells including BMMs (osteoclast precursor cells) (Supplementary Fig.2a–g). In vitro cultures of BMMs from WT ...
RA is estimated to affect approximately 0.24–1% of the population and is twice as common in women than men3. It is a chronic autoimmune disease characterized by inflammatory polyarthritis that preferentially affects the small joints4. The clinical symptoms of OA and RA are similar and sometimes...
Patients diagnosed with degenerative hypertrophic OA (M 17, according to International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) Version for 2014 of bone joints and verified by radiography (Grade I -III by Kellgren-Lawrence, 2007 radiographic grades [53...
Hand OA is characterized by the involvement of multiple joints, in particular distal (DIP's) and proximal (PIP's) interphalangeal joints and first carpometacarpal joints (CMC1's)2, 3. The disease causes a high clinical burden1, 4 with symptoms such as pain and stiffness, loss of mobility...
They contain information about ICD-10 diagnosis, prescription of medication, physical therapy and medical aids, age and sex, hospitalization, and information on the contact to physicians and their medical specialty. However, claims data cannot offer information on disease activity, clinically validated ...
, knee and hip joint are weight-bearing joints, and excessive obesity may increase the risk of osteoarthritis by increasing joint load [37]. Although fat mass and basal metabolic rate cannot be equated with obesity, bias in the causal association between MAPK3 and knee OA should still be ...
International Journal of Molecular Sciences Article Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways Pu-Rong Chiu 1,2, Yu-Chen Hu 2, Tzu-Ching Huang 1,2, Bau-Shan Hsieh 2, Jou-Pei Yeh 2, Hsiao-Ling Cheng 3, Li-Wen Huang 4,*,† ...