subchondral bone structural changes, osteophytes formation, joint inflammation, and impaired function5. Chondrocytes, the sole cell type in articular cartilage, play a crucial role in maintaining the structure and function of cartilage6. In OA, there is an imbalance in the metabolism of the cartilag...
The associations of selected genetic instruments with OA and RA were estimated in UK Biobank. Diagnosed diseases status was recorded in the hospital episode statistics as the International Classification of Diseases (ICD) codes. We mapped these ICD codes to the phecode grouping system, which merges...
Osteoarthritis (OA), a degenerative age-related disease that affects the joints, is the most common human musculoskeletal disorder and a leading cause of disability in elderly populations worldwide. The symptoms of OA include pain, morning stiffness, joint swelling, limited range of motion, decreased...
To achieve this, we utilized a linked dataset of claims data and survey data. Two stratified random samples (axSpA, ICD-10 Code M45, OA of the hip, knee or polyarticular OA (ICD-10 codes M15-17)) were selected from the population of over 7 million insurants aged 18–79 who were ...