A protein member of the dickkopf family, DKK-1, is known for its inhibitory activity of Wnt signaling, a master regulatory pathway of joint homeostasis and a potential drug target in KOA, since active Wnt pathway promotes cartilage breakdown [55]. DKK-1 is inversely correlated with KOA ...
F. Echtermeyer et al., Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nature medicine 15, 1072 (Sep. 2009). A. C. Lin et al., Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nature medicine 15, 1421 (Dec. 2009). T. Saito...