osteolineage cell 是什么细胞?骨系细胞，来自间充质干细胞，可分化为成骨细胞、软骨细胞、脂肪细胞[1]...
Osteolineage cell-derived extracellular vesicles (EVs) play a regulatory role in hematopoiesis and have been shown to promote the ex vivo expansion of human hematopoietic stem and progenitor cells (HSPCs). Here, we demonstrate that EVs from different human osteolineage sources do not have the same...
Expression and function of a stem cell promoter for the murine CBFa2 (runx1) gene: distinct roles and regulation in natural killer and T cell development. The Runt family transcription factor CBFalpha2 (AML1, PEBP2alphaB, or Runx1) is required by hematopoietic stem cells and expressed at ...
Haematopoietic stem cells (HSCs) can differentiate into cells of all lineages in the blood. However, the mechanisms by which cytokines in the blood affect HSC homeostasis remain largely unknown. Here we show that leukocyte cell-derived chemotaxin 2 (LECT
(g) The mRNA levels of BM cell markers in CD209a þ BM cells relative to the level in steady-state BM cells. CD169, a marker of macrophages; RunX2, a marker of osteolineage cells; nestin, a marker of mesenchymal stem or stromal cells; calcitonin receptor (CTR), a marker of ...
Recent studies have implicated bone-lining osteoblasts as important regulators of hematopoietic stem cell (HSC) self-renewal and differentiation; however, because much of the evidence supporting this notion derives from indirect in vivo experiments, which are unavoidably complicated by the presence of ...
This provides a robust platform in our established AML NSG xenograft model (using Molm14, HL60 or U937 cell lines) for a direct analysis of two principle mesenchymal populations known to be involved in leukemia drug resistance. At a leukemic burden of 60-90% in the BM, we initially ...
Osteolineage niche cells initiate hematopoietic stem cell mobilization Recent studies have implicated bone-lining osteoblasts as important regulators of hematopoietic stem cell (HSC) self-renewal and differentiation; however, ... SR Mayack,AJ Wagers - 《Blood》 被引量: 247发表: 2008年 Regulation of...
There is evidence suggesting that N-cadherin expression on osteoblast lineage cells regulates hematopoietic stem cell (HSC) function and quiescence. To test this hypothesis, we conditionally deleted N-cadherin (Cdh2) in osteoblasts using Cdh2flox/flox Osx-Cre mice. N-cadherin expression was efficient...
osteolineage cell 是什么细胞?骨系细胞，来自间充质干细胞，可分化为成骨细胞、软骨细胞、脂肪细胞[1]，能产生细胞外囊泡、参与造血过程，包括造血干细胞增殖的启动和调节等关键步骤[2][3]。图片来源[4]参考 ^Asada, N., Katayama, Y. Regulation of hematopoiesis in endosteal microenvironments. Int J ...