Vertebrate skeletal elements are formed through two distinct processes: intramembranous and endochondral ossifications1,2. Intramembranous ossification is the process by which mesenchymal cells differentiate into osteoblasts and is consequently responsible for the formation of the clavicle and most of the crani...
Furthermore, the effects of miR-203 were completely blocked by Runx2 siRNA transfection, suggesting that the function of miR-203 in osteoblast differentiation is Runx2 dependent (Figure 4g). Clinical HO samples exhibit elevated Runx2 expression and activated β-catenin and ERK signaling. HO ...
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by the anomalous differentiation of mesenchymal progenitor cells and resulting in the formation of ectopic bone in non-skeletal tissues. This abnormal bone growth contributes to pain and...
An additional round of double- sided SPRI bead cleanup is performed after end repair and A- tailing. Another single-sided cleanup is done after adapter ligation. Indexes were added during PCR amplification and a final double- sided SPRI cleanup was performed. Libraries were quantified by Kapa ...
The longitudinal growth of the anterior column of the spine, including the growth of the vertebral body, is mainly due to the development of the vertebral growth plate by endochondral ossification, while the longitudinal growth of the posterior column is mainly derived from the articular cartilage....
Yangbai Sun*, Jiangyu Cai*, Shiyang Yu, Shuai Chen, Fengfeng Li & Cunyi Fan Heterotopic ossification (HO) is the abnormal formation of mature bone in extraskeletal soft tissues that occurs as a result of inflammation caused by traumatic injury or associated with genetic mutation...
cells during development.12 The skeleton is composed of cartilage and bone, and the development of these two cell types is coordinated by a network of signaling pathways and transcrip- tion factors.13 Bone is remodeled by the coupling of two opposing processes: bone resorption and bone formation...
Acquired heterotopic ossification (HO) is a painful and debilitating disease characterized by extraskeletal bone formation after injury. The exact pathogenesis of HO remains unknown. Here we show that TGF-β initiates and promotes HO in mice. We find that calcified cartilage and newly formed bone ...