The ORION-9 trial, in patients withfamilial hypercholesterolemia(FH), is the subject of its own paper, while the ORION-10 and ORION-11 studies, in patients with or at risk foratherosclerotic cardiovascular disease, are reported together in one publication. Preliminary results from all three trial...
研究的主要有效性终点为从仅inclisiran治疗组患者从ORION-1研究开始至开放标签拓展研究阶段的第210天内LDL-C水平的变化百分比(意向治疗分析人群的inclisiran暴露时间约为570天)。次要和探索性终点还包括随访1440(4年)内的LDL-C和PCSK9...
Start a Free Trial Included in the Advantage Stack Leverage Risk Intelligence and its integrations to their fullest capacity with the Orion Advantage Stack. In addition to the full Risk Intelligence suite listed in the standalone offering, you also get: Access to the Orion Compare Tool Pre-...
*In response to COVID-19 through July 1: free for educators, recording limit removed on the free plan, free trial extended to 30 days, Loom Pro price adjusted to $5/month RING CENTRAL– $24.99-49.99 PER USER* Services Provided:Video Conferencing | Web Conferencing/Webinar | Audio/Phone |...
Inclisiran便是利用上述的RNA干扰机制,从上游精准阻断肝脏PCSK9蛋白的合成,从而使肝细胞表面LDL受体表达增加,降低血液LDL-C水平(图3)[8-10]。 图3. 小干扰RNA在mRNA层面精准调控基因表达 三、GalNAc递送系统: 靶向肝脏,降低脱靶 除了能精准实现基因表达调控外,inclisiran还具有肝脏靶向性,使其能够定向递送至肝脏...
Originally from Lake Orion, Michigan, the designer always looked toward Heaven for inspiration. The name“Orion Golf”has it’s origin in the“Hunter”… also known as the constellation“Orion”. TheHunterhas his weapon, aclub… perhaps if he was a golfer… aBlack Swan. ...
GET IT NOW –FREE 60-DAY TRIAL! Already a user? Log in FREE EMESIS INDUCTION GUIDE! Induction of emesis in dogs is often the first step of decontamination following ingestion of potentially toxic substances. We’ve put together a table of some common poisonous substances with their typical tim...
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首先,我们做一个术语约定,我们称从坛子里抽一次球为一次试验(trial),nn次试验构成一次实验(experiment)。我们接下来会先考察无放回抽样(sampling without replacement) 实验,也即从有NN个球的坛子里无放回地抽nn个球,我们会发现实验结果服从超几何分布/广义超几何分布。接着,我们会讨论前向推断和后向推断两类问题...