Chang-HuiShen, inDiagnostic Molecular Biology (Second Edition), 2023 Origin of replication The origin ofDNA replicationis the location where DNA duplication begins (Fig. 5.18). Once the replication is initiated, DNA replication is bidirectional, proceeding away from theorigin of replicationin both di...
Replication without RNAStationary stateThere are diverse opinions regarding the definition of life's origin, and it is often said that such definition is crucially dependent on how one defines life. We suggest here a stand-alone definition for the origin of life, irrespective of how "life" is ...
ResearchOpen Access29 Jul 2023Communications Biology Volume: 6, P: 788 All Research & Reviews News and Comment Replication licensing during S phase: breaking the law to prevent breaking DNA A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading dur...
Melvin L.DePamphilis, inCurrent Topics in Developmental Biology, 2016 7Both Genetic and Epigenetic Parameters Define Replication Origins DNAreplication originsin bacteria,archaea, plasmids, bacteriophage, and viruses are specific sequences essential for initiation of DNA replication, because they containbind...
Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle. Origin choice is linked to cell growth, differentiation, and replication stress. Although various genetic and epigenetic
With advances in synthetic biology and genome engineering comes a heightened awareness of potential misuse related to biosafety concerns. A recent study employed machine learning to identify the lab-of-origin of DNA sequences to help mitigate some of the
While there are a number of genome-wide profiling approaches that can be used to identify allele-specific expression, there are several significant challenges for the definition of novel imprinted genes [28]. To distinguish between allele-specific expression effects that are either parent-of-origin ...
DNA Replication: Eukaryotic Origins and the Origin Recognition Complex I.Chesnokov,A.Svitin, inEncyclopedia of Biological Chemistry (Second Edition), 2013 Origin Recognition Complex as the Core of Replication Initiation Machinery ORC Discovery, Conservation, and Structure ...
(1.5 um) suggesting the possibility of endoreplication54. Similarly, a wide range of nuclear sizes has also been observed in various life stages ofA. whisleri(unpublished data) andP. gemmata37. The cells ofD. cyprini,D. percae, andS. destruensgo through nuclear division at least twice. ...
The large and diverse land plant lineage is nested within a clade of fresh water green algae, the charophytes. Collection of genome-scale data for land plants and other organisms over the past decade has invigorated the field of evolutionary biology. One of the core questions in the field ask...