Replication without RNAStationary stateThere are diverse opinions regarding the definition of life's origin, and it is often said that such definition is crucially dependent on how one defines life. We suggest here a stand-alone definition for the origin of life, irrespective of how "life" is ...
These biological constituents do not function independently but interact to influence tumor progression by secreting various chemical factors, chemokines, exosomes, etc. Briefly, the cellular composition and functional status of TME varies depending on a range of conditions such as the site of tumorigenes...
initiated at the highly structured 5′-UTR, generate polyproteins Orf1a and Orf1ab that are proteolytically cleaved to generate the viral replication-transcription complex (RTC) (Fig.1a)9. Central to the synthesis of ORF1
PIs target the active site of the HIV-1 protease (PR). Protease activity is essential for the generation of full infectious viral particles through the cleavage of Gag and Gag-pol polyproteins. Despite the high genetic barrier of the PI, the emergence of mutations at the protease active site...
We recently identified two recurrent somatic mutations in the H3F3A gene, affecting highly conserved residues of its encoded protein, the replication-independent histone 3 variant H3.3, in one-third of pediatric GBMs (Schwartzentruber et al., 2012). Mutations in a protein complex comprised of ...
Specific signals at the 30 end of the DHFR gene define one boundary of the downstream origin of replication. Gen Dev 2005; 19:1053-66; PMID:15879555; http://dx.doi.org/10.1101/gad.1307105Mesner LD, Hamlin JL. 2005. Specific signals at the 39 end of the DHFR gene define one boundary ...
In the light of this criterion, I suggest that there is no firm evidence for the proposal that there exist two different proteins which are required for initiation of DNA replication in Escherichia coli.doi:10.1016/0022-5193(74)90143-XStephen Cooper...
Quadruplet codons: One small step for a ribosome, one giant leap for proteins: an expanded genetic code could address fundamental questions about algorithmic information, biological function, and the origins of life. Bioessays 2010, 32, 650–654. [CrossRef] [PubMed] 123. Santos, M.A.; ...