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Cancer Cell 8: 241-254 Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins are mechanotransducers that regulate cell fate, we asked whethe... MJ Paszek,N Zahir,KR Johnson,... - 《Cancer Cell》 被引量: 684发表: 2005年 加载更多...
The urinary system, is a group of organs in the body that filters out excess fluid and other substances from the bloodstream. The purpose of the renal / urinary system is to eliminate wastes from the body, regulate blood volume and pressure, control levels of electrolytes and metabolites...
the pancreas is an endocrine organ that exists within the abdominal cavity. It secretes several hormones, including insulin and gulcagon. Both insulin and glucagon help to regulate blood sugar levels; insulin decreases blood sugar when it gets too high, and glucagon increases it when it gets too...
___ 9 Skin cells protect against injury and ultraviolet light 9 Protect the body from water loss and pathogens ___ 9Skin cells form glands that secrete mucus, oil, and sweat ___ 9Cells in the blood vessels and intestines absorb nutrients Epithelial Tissue ¾ There is ...
and hematopoietic stem cells have been rescued after exposure to the blood of a younger animal using a parabiosis model174. As noted before, the reactivation of Wnt in the intestine is capable of rejuvenating aged ISC32. In other organs, it is known that aging promotes the development of pro...
This motif, which binds the calcium ion , is found in several proteins that regulate cellular activity via changes in calcium ion concentrations. Many proteins that bind to deoxyribonucleic acid (DNA) and regulate gene expression incorporate a zinc finger motif. As the name implies, this motif ...
Since multiple cytokines as well as TCR signalling are reported to downregulate S1pr1 expression16,26, it is possible that distinct microenvironments might retain CD4 þ T cells in distinct lymphoid tissues. Here we describe a population of antigen-experienced CD4 þ T cells with a distinct ...
This causes liver injury to occur because the enzymes that require NAD+ as a cofactor such as the sirtuin de-acetylases cannot de-acetylate acetylated proteins such as acetylated histones. This prevents the epigenetic changes that regulate metabolic processes and which prevent organ injury such as...
It is possible that action at the calcium channel could potentially cause any neuron to release its neurotransmitters, thus making MDMA messy indeed. Affinity for the calcium channel may also be responsible for MDMA’s toxicity: “… if too much calcium enters the cell through open channels, it...