Bone remodelingReceptor activator of nuclear factor κB ligand (RANKL)Osteoprotegerin (OPG)The interaction between receptor activator of nuclear factor 魏B ligand (RANKL) and osteoprotegerin (OPG) plays a dominant role in osteoclastogenesis. As both proteins are produced by osteoblast lineage cells, ...
according to the “seed and soil” hypothesis [147]. In this context, impaired regulation of RANKL/RANK/OPG system and excessive osteoclast-induced bone resorption have been shown to play an important role in promoting bone metastasis
The expression of bone formation markers was activated in the bone formation phase, followed by the stimulation of RANKL/OPG expression in the bone resorption phase, which confirmed that these molecules are key factors linking bone formation to resorption during bone remodeling. 展开 ...
然而,p53基因影响MSCs细胞分化、微环境塑造的作用和机制尚不明确。 2020年7月22日,国际著名学术期刊Cell Death & Differentiation在线发表了中国科学院上海营养与健康研究所王莹、时玉舫课题组题为“Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoproteg...
成骨细胞与骨细胞【osteocytes】一起充当机械传感器【mechanical sensors】和骨骼重塑过程的协调者【coordinators for the bone remodeling process】,后者由局部生长因子【local growth factors】和全身性因素控制,例如降钙素【calcitonin】或雌激素...
To investigate the blood levels of bone remodeling factors (RANKL, OPG and Bone-ALP) in psoriatic arthritis patients. Included in this study were 27 patients with psoriatic arthritis (CASPAR classification criteria) and 20 healthy subjects. The RANKL , OPG and Bone-ALP levels have been quantified...
【Key words】 Osteoporosis; Bone remodeling; Osteoprotegerin; RANK 一,骨质疏松症的流行病学 骨质疏松症是一种与年龄相关的慢性全身性代谢性疾 病,它主要以骨量减少,骨微结构破坏和骨脆性增加为特 征.由于其发病率和死亡率的提高,该病已经成为全球性的 公共健康问题 .[1] 目前全球范围内骨质疏松症人群已超过...
2020年7月22日,国际著名学术期刊Cell Death & Differentiation在线发表了中国科学院上海营养与健康研究所王莹、时玉舫课题组题为“Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin”的最新研究成果。该研究首次揭示了p53通过调控osteoprotegerin(O...
comparedwiththebaselinemeasurements.ConclusionOPGisoneofthekeymediatorsresponsibleforalveolarboneremodelingduringtoothmovement.Keywords:orthodontictoothmovement;OsteOprOtegerin:gingivalcrevicularfluid;periodontalligament龈沟液(GingivalCrevicularFluid,GCF)是通过牙龈沟内上皮和结合上皮从牙龈结缔组织渗入到龈沟内...
RANKL/RANK/OPG pathway: A mechanism involved in exercise-induced bone remodeling [J]. Biomed Res Int, 2020, 2020: 6910312. [8] Ono T, Hayashi M, Sasaki F, et al. RANKL biology: Bone metabolism, the immune system, and beyond [J]. Inflamm Regen, 2020, 40: 2. [9] Azizieh F Y,...