T cell development on OP9-DL1 cells.Alexandra, BergerCatherine, FrelinDivya, K. ShahPatricia, BenvenisteRobert, HerringtonNorma, P. GerardJuanCarlos, ZúñigaPflückerNorman, N. IscoveChristopher J., Paige
The OP9-DL1 culture system is an in vitro model for T-cell development in which activation of the Notch pathway by Delta-like 1 promotes differentiation of mature T cells from progenitors. The roles of specific cytokines in this culture system have not been well defined, and controversy...
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OP9-DL1 is a murine stromal cell line that mimics thymic microenvironments to support T cell development in vitro and provides a useful tool to study T lymphocyte lineage commitment [14] and thymic adipogenesis [31, 38]. In order to identify key regulators in thymic adipogenesis, the present...
De-Smedt M,Hoebeke I and Plum J.Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells Molecules Diseases . 2004De Smedt M, Hoebeke I, Plum J. Human bone marrow CD34+ progenitor cells mature to T cells on OP...
Spangrude, Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system, Exp. Hematol. 34 (2006) 1730-1740.Wang H,Pierce LJ,Spangrude GJ.Distinct roles of IL-7and stem cell factor in the OP9-DL1T-cell differentiation culture system.Experimental ...