Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells Mol Dis 2004 ; 33 : 227-32.De Smedt M, I Hoebeke and J Plum. (2004). Human bone mar- row CD34+ progenitor cells mature to T cells on OP9-DL1 stro...
OP9-DL1 is a murine stromal cell line that mimics thymic microenvironments to support T cell development in vitro and provides a useful tool to study T lymphocyte lineage commitment [14] and thymic adipogenesis [31, 38]. In order to identify key regulators in thymic adipogenesis, the present...
Cell LineHumansDNA-Binding ProteinsCD40 LigandReceptors, Antigen, T-Cell, alpha-betaReceptors, Interleukin-2Human CD34+ hematopoietic precursor cells cultured on delta-like ligand 1 expressing OP9 (OP9-DL1) stromal cells differentiate to T lineage cells. The nature of the T cells generated in ...