working with a pair of colleagues from the University of North Carolina at Chapel Hill, has developed a type of "smart" insulin that when tested in mouse and minipig models successfully regulated blood glucose levels for up to one week after just one injection. ...
A study published in finds that a single daily injection of insulin (insulin glargine) is just as good at helping patients control blood sugar as an injection that must be administered up to three times a day (insulin lispro). Professor Reinhard G Bretzel (Justus-Liebig-Universit盲t Giessen,...
we show that a subcutaneous depot formed after a single injection of GLP1 recombinantly fused to a thermosensitive elastin-like polypeptide results in zero-order release kinetics and circulation times of up to 10 days in mice and 17 days in monkeys. The optimized pharmacokinetics lead to 10 days...
"We had excellent absorption results for the slow-acting form—about 50% better than injection delivery for the same quantity of insulin," Conn said. The capsule achieved good absorption results for fast-acting insulin, but the significant lag in the insulin taking effect compared with injection ...
Switching from a progestin only method (progestin only pill, injection, implant, or intrauterine system): Insert ring at the time of either: The next oral pill would be taken, the implant or intrauterine system is removed, or at the next scheduled injection. Back-up barrier contraception should...
In tests, pigs were given the injectors directly, rather than within a pill capsule. The injectors succesfully delivered insulin to the blood of these animals. The pigs showed no signs of pain and their stomachs looked normal when they were examined by endoscope a week after they w...
The exclusion criteria were women who had an abortion in the last two weeks, had not menstruated after delivery, had not menstruated after stopping oral or injection contraceptives, or participated in other studies during the last 6 months. Other exclusion criteria were the presence of any ...
Ketamine can be mixed with medetomidine, xylazine or acepromazine and the combination administered as a single injection. Long-term administration of ketamine can result in bladder irritation (Morgan & Curran, 2012), and these effects have been reported after 2–3 week administration to rats (...
脱氢表雄酮: 一种AR激动剂、ERs激动剂药物,由Endoceutics, Inc. (Endoceutics, Inc.)公司最早进行研发,目前全球最高研发状态为批准上市,作用机制: AR激动剂(雄激素受体激动剂),ERs激动剂(雌激素受体家族激动剂),治疗领域: 内分泌与代谢疾病,皮肤和肌肉骨骼疾病,泌尿生殖
The rats were divided into two groups (n=7): 1) control group (C, these rats served as controls) and 2) exercised group (RIE, these rats performed a high-intensity exercise for one month (5 days per week) 40 min daily with speed 35 m/min. The total exercise time was 60 min. ...