analysis, and conclusions derived from large-scale datasets. The integration and analysis of large-scale datasets such as genomic, radiomic/radiogenomic, digital pathology, real-world, and EHR datasets requires advanced computational tools and increased power, owing to their complexity and heterogeneity...
And the incidence of treatment-related adverse reactions was similar between the two groups, suggesting that the combination therapy did not significantly increase toxicity [150]. Therefore, this combination regimen can be considered for patients who respond to enzalutamide but later experience progression...
M. Immune-checkpoint inhibitors: long-term implications of toxicity. Nat. Rev. Clin. Oncol. 19, 254–267 (2022). PubMed PubMed Central Google Scholar Bray, F. et al. Global cancer statistics 2022: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. ...
analysis, and conclusions derived from large-scale datasets. The integration and analysis of large-scale datasets such as genomic, radiomic/radiogenomic, digital pathology, real-world, and EHR datasets requires advanced computational tools and increased power, owing to their complexity and heterogeneity...
Dose-limiting toxicity NPC: Nasopharyngeal carcinoma CC: Cervical cancer VH: Variable heavy VL: Variable light MTD: Maximum tolerated dose DCR: Disease control rate PopPK: Population pharmacokinetics Cmax: Maximum concentration Tmax: Time to maximum concentration AUC: Area under the time...
In terms of side effects, a total of five patients experienced grade 3 toxicity. One showed acute toxicity (ataxia), whereas late toxicity (neuropathy, cognitive disturbance, optic nerve disorder, or seizure) surfaced in the other four. No acute or delayed grade 4 or 5 toxicities were ...
(beta =−886, p<0.001), and other patient- reported toxicity scores Step counts decreased by 54 steps/day from baseline (RT planning simulation) during RT (p<0.001) (clinically nonrelevant due to large number of data points); sleep amount did not correlate with activity levels Patients ...
(beta =−886, p<0.001), and other patient- reported toxicity scores Step counts decreased by 54 steps/day from baseline (RT planning simulation) during RT (p<0.001) (clinically nonrelevant due to large number of data points); sleep amount did not correlate with activity levels Patients ...
Nurses should be able to recognize signs and symptoms of adverse drug reactions and determine severity using the CTCAE (Common Terminology Criteria for Adverse Events) toxicity scale. Further, nurses caring for research participants can help champion safety and protocol compliance through...
This urgency highlights the need for a personalized treatment approach, which may offer the highest likelihood of cure while minimizing potential toxicity to the patient. However, the development of personalized strategies faces hurdles due to the difficulty of generalizing approaches derived from data ...