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An Expanded View of Complex Traits: From Polygenic to Omnigenic “A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease-causing variants to cluster into key pathways that drive disease etiology. But for complex traits, ass...
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Gene expression predictions and networks in natural populations supports the omnigenic theory Aurélien Chateigner, Marie-Claude Lesage-Descauses, Odile Rogier, Véronique Jorge, Jean-Charles Leplé, Véronique Brunaud, Christine Paysant-Le Roux, Ludivine Soubigou-Taconnat, Marie-Laure Martin...
095 causal SNP–gene-disease triplets (with S2G-derived functional interpretation) with high confidence. We further applied cS2G to provide an empirical assessment of disease omnigenicity; we determined that the top 1% of genes explained roughly half of the SNP heritability linked to all genes and...