Omnigenic modelNeurodegenerative diseasesAlzheimer's diseaseParkinson's diseaseRecently, a seminal model, called the omnigenic model, is proposed for understanding complex traits such as schizophrenia. In this study, we examined this model in Alzheimer's disease and Parkinson's disease from the ...
A recent development in the genetic architecture of schizophrenia suggested that an omnigenic model may underlie the risk for this disorder. The aim of our study was to use polygenic profile scoring to quantitatively assess whether a number of experimentally derived sets would contribute to the ...
“A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease-causing variants to cluster into key pathways that drive disease etiology. But for complex traits, association signals tend to be spread across most of the genome—i...
On the one hand, genes that are better predictors with an additive model are supposed to have an overall less redundant, more additive, direct mode of action. On the other hand, genes being better predictors with an interactive model are supposed to operate with high pervasiveness and ...
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking strategies have been developed to link regulatory SNPs to the genes that they regulate
The recently proposed omnigenic model provides a conceptual framework to explain these observations by postulating that numerous distant loci contribute to each complex trait via effect propagation through intracellular regulatory networks. We formalize this conceptual framework by proposing the "quantitative ...
many genes of moderate or small effects contribute to the phenotype.1, 2, 3, 4 Hence, the attention has turned toward the loci falling below the GWA cut-off, which may contribute to the phenotype through modifier interactions with a set of core genes, as proposed in the omnigenic model. ...
doi:10.20900/JPBS.20170014S7Barbara FrankeJournal of Psychiatry and Brain ScienceFranke B. What's in a Name: the "Omnigenic" Model as a Point of Departure for Polygenic Psychiatric Disorders. JPBS. 2017. doi:10.20900/jpbs.20170014(S1-S8)...
Psychiatric disordersSchizophreniaIn 1996, Dr. Costa was invited by Prof. Boris Astrachan, Chairman of the Department of Psychiatry at the University of Illinois at Chicago, to direct the research of the "Psychiatric Institute, Department of Psychiatry, School of Medicine, at the University of ...
As such, our results are consistent with the omnigenic model.Mhler, NiklasSchiffthaler, BastianRobinson, Kathryn M.Terebieniec, Barbara K.Vuak, MatejMannapperuma, ChanakaBailey, Mark E. S.Jansson, StefanHvidsten, Torgeir R.Street, Nathaniel R....