One avenue to explore MIC and MIC inhibition is through the application of omics-based techniques, where insight into the bacterial population in terms of diversification and their metabolism can be further understood. As such, this paper discusses the recent progresses made in a number of fields ...
Biomedicine and pharmacotherapy - Vol. 141 - N° C - Article : 111833 - Application of omics- and multi-omics-based techniques for natural product target discovery - EM consulte
Due to low success rates and long cycles of traditional drug development, the clinical tendency is to apply omics techniques to reveal patient-level disease characteristics and individualized responses to treatment. However, the heterogeneous form of data and uneven distribution of targets make drug dis...
Due to low success rates and long cycles of traditional drug development, the clinical tendency is to apply omics techniques to reveal patient-level disease characteristics and individualized responses to treatment. However, the heterogeneous form of data and uneven distribution of targets make drug dis...
Furthermore, this paper discusses the required improvements in research strategy, i.e., path and drug discovery processes, omics-based techniques, and systems biomedicine methodologies. Firstly, novel methods should be employed to examine the networks that control and modulate the immune, O&NS and ...
Integrated Multi-Omics Perspective to Strengthen the Understanding of Salt Tolerance in Rice 2022, International Journal of Molecular Sciences Multi-Omics Techniques for Soybean Molecular Breeding 2022, International Journal of Molecular Sciences View all citing articles on ScopusView...
Rapid and recent advances in molecular profiling strategies and analytical techniques based on high-throughput sequencing and mass spectrometry (MS) development have generated large-scale multi-omics datasets, mainly emerging from the three ”big omics”, based on the central dogma of molecular biology...
PCR-based techniques are often used for the validation of these biomarkers. Among the genetic markers for CRC are APC, TP53, KRAS, BRAF, and PIK3CA. In relation to transcriptomic markers, miRNAs stand out, consisting of short noncoding RNAs, such as miR-21, miR-92a, miR-103a-3p, miR-...
Many "omics" techniques have been developed for one goal: biomarker discovery and early diagnosis of human cancers. A comprehensive review of mass spectrometry-based "omics" approaches performed on various biological samples for molecular diagnosis of human cancers is presented in this article. Further...
Our objective is to gain insights into this pathological condition, combining different omics techniques including single-cell RNA sequencing (scRNA-seq), spatial transcriptomics and laser capture microdissection-coupled mass spectrometry (LCM–MS) with different sample sets (Extended Data Fig. 1 and ...