Colorectal cancerOmicsTranscriptomicsBiomarkersMicrobiotaColorectal cancer (CRC) ranks third among the most commonly occurring cancers worldwide, and it causes half a million deaths annually. Alongside mechanistic study for CRC detection and treatment by conventional techniques , new technologies have been ...
A molecular hallmark of cancer is the presence of genetic alterations in the tumoral DNA. Understanding how these alterations translate into the malignant phenotype is critical for the adequate treatment of oncologic diseases. Several cancer genome sequencing reports have uncovered the number and identity...
Immunotherapy and Cancer: The Multi-Omics Perspective Immunotherapies have revolutionized cancer treatment approaches. Because not all patients respond positively to immune therapeutic agents, it represents a ... C Donisi,A Pretta,V Pusceddu,... - 《International Journal of Molecular Sciences》 被引量...
According to proteomic and transcriptomic analyses, targeted replication stress has great potential as a liver cancer therapy.Through unbiased Kinome CRISPR-CAS9 library screening, we identified the combination of WEE1 inhibitors and oxaliplatin as a novel treatment strategy for liver cancer targeting ...
Breast cancer (BC) is a leading cause of cancer-related death worldwide. The diverse nature and heterogeneous biology of BC pose challenges for survival prediction, as patients with similar diagnoses often respond differently to treatment. Clinically relevant BC intrinsic subtypes have been established...
to identify molecular pathways that are deregulated in cancer which will not only elucidate underlying tumorigenic mechanisms, but may also help to determine the classes of drugs that are used for cancer treatment (Furge et al. 2007). It is a challenge for genomics studies to identify unique...
The high metastasis of breast cancer has been a significant challenge for clinical treatment55. Based on the potent immune response of the pyroptosis inducer, we investigated the prospect of MG@PM versus clinical first-line therapy, anti-PD-1/Abraxane, in murine lung metastasis models56,57. Foll...
From cooperation on soybean breeding with Thailand to collaboration with Europe on optical fibers, from providing communication services via satellite in Algeria to jointly exploring new perspectives on prevention and treatment of cancer in China's space station, China has been honoring its commitments ...
NMT2re-expression is toxic to NMT2-deficient cancer cells andNMTKO sensitizes cells to PCLX-001 treatment. NMT2-deficient cells BL2 viability after expressingNMT2compared to NMT2-normal IM9 cells (p = 0.0095) (A). BL2 cancer cells were grown for 6 months with increasing concentrations...
functional components of TME. It is crucial to focus on the role of senescent cells and to utilise these mechanisms to achieve direct or adjuvant treatment of tumours. For example, pharmacologic and immunologic targeted ablation or remodelling of the SASP process to achieve anti-cancer effectiveness...