因此,OMA1-DELE1-HRI途径是一个潜在的治疗靶点,可以对涉及线粒体功能障碍的疾病的有益结果的综合应激反应进行微调。 爱必信生物为您提供优质的新冠疫情相关产品,助力您的对于新冠病毒的研究: 疫情相关因子ELISA检测试剂盒: abs510006 Human TNF-α ELISA Kit 96T abs510002 Human IL-1 beta ELISA kit 96T abs5100...
整合性应激反应膜蛋白DELE1在最近一项来自加州大学旧金山分校的Martin Kampmann团队的研究中,作者发现了介导线粒体损伤信号传递到细胞质以激活整合性应激反应(integrated stress response,ISR)的信号通路.该通路主要依赖于一个未被充分研究的线粒体内膜蛋白DELE1,其在线粒体损伤的情况下被线粒体蛋白酶OMA1切割成短肽...
Blockade of the OMA1–DELE1–HRI pathway triggers an alternative response in which specific molecular chaperones are induced. The OMA1–DELE1–HRI pathway therefore represents a potential therapeutic target that could enable fine-tuning of the integrated stress response for beneficial outcomes in ...
Guo等人的研究表明HRI是eIF2α的激酶。通过CRISPRi筛选,鉴定到HRI的上游因子OMA1。OMA1蛋白位于线粒体内膜上,是受线粒体胁迫激活的蛋白酶。线粒体胁迫会激活OMA1介导的DELE1蛋白的切割,DELE1蛋白在细胞质中积累,并与HRI互作,激活其激酶活性。OMA1-DELE1-HRI通路可以作为线粒体功能障碍疾病的潜在治疗位点。 通过...
Mitochondrial dysfunction is signaled to the integrated stress response by OMA1, DELE1 and HRIdoi:10.1101/715896Xiaoyan GuoGiovanni AvilesYi LiuRuilin TianBret A. UngerYu-Hsiu T. LinArun P. WiitaKe XuM. Almira CorreiaMartin KampmannCold Spring Harbor Laboratory...