Anaplastic oligodendrogliomas (AO) are uncommon primary brain tumors whose natural history, prognosis, and optimal management are not yet fully understood. However, they are associated with a better prognosis and response to multimodality therapy based on specific molecular changes. In this multicenter ...
Therapy and prognosis Low-grade ODs are usually managed with surgery alone, whereas high-grade tumors are treated aggressively with surgery, radiation therapy, and chemotherapy. Ten-year survival rate is 85% for low-grade OD, 42% for tumors having undergone malignant transformation, and 15% for ...
Other analyses from this study also suggested that deletion of CDKN2A (p16 protein) and the presence of a ring-enhancing tumor conferred significantly worse prognosis. These observations demonstrated for the first time that specific molecular genetic changes may be used as markers of chemosensitivity ...
These toxicities are particularly important for patients with low-grade oligoden-drogliomas in whom the prognosis often exceeds 10 years. Consequently, with the accumulating evidence supporting the chemosensitivity of low-grade and anaplastic oligodendrogliomas and the recent ability to use molecular ...
Oligodendrogliomas are a distinct subgroup of brain tumors with a fairly favorable clinical prognosis. However, these tumor exhibit varying degrees of heterogeneity and their clinical behavior is therefore not always the same. For this reason, genetic markers have been developed to further guide the ...
(i.e., oligodendrogliomas), have a very favorable outcome where the sameTERTmutations in the absence of this codeletion orIDHmutations herald a grim prognosis (comparable to glioblastoma) [70].TERTmutations are mutually exclusive withATRX(alpha thalassemia mental retardation syndrome X linked) ...
cells that are actively dividing and growing. Molecular profiling reveals DNA mutations that help predict tumor behavior and prognosis. These include:IDH1,IDH2,ATRX,1p/19q codeletion,EGFR, MGMT,and TERT. On average, patients who have IDH, MGMT, and 1p/19q mutations have a better prognosis. ...
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delayed, and extent of tumor resection and how it correlates with prognosis. In order to avoid repetition, this chapter will focus on issues specifically relevant to OD/OA. Access through your organization Check access to the full text by signing in through your organization. Access through ...
This chapter describes the oligodendrogliomas, its frequency and incidents, molecular genetics, clinical features and natural history, management, and prognosis of OD. Though diffuse WHO grade II gliomas have traditionally been grouped together, but the realization that there are clinically relevant ...