stages of non-REM sleep, and quetiapine reducingREM sleep. Both medications have significant potential risks includingakathisia, weight gain,orthostatic hypotension, andanticholinergiceffects. In addition, concerns about contributions to nocturnal leg movements (through dopamine antagonism) or sleep-...
Taylor D.Haloperidol,olanzapine and risperidone reduce treatment failure compared to aripiprazole,quetiapine and ziprasidone in acute schizophrenia.Evidencebased ... Taylor,D P. - Evidence-based mental health 被引量: 16发表: 2007年 The effects of second generation antipsychotic drugs on sleep variables...
However, the risk is lower with olanzapine and quetiapine because they cause greater sedation. Risperidone is indicated for acute manic or mixed episodes associated with bipolar I disorder. Aripiprazole, asenapine, cariprazine, lurasidone, olanzapine, and risperidone are also used for schizophr...
Olanzapine, a thienobenzodiazepine derivative, is a second generation (atypical) antipsychotic agent which has binding affinity for a broad range of neurotransmitter receptors. It has significantin vitroinhibitory activity at dopamine D2, D3, D4, serotonin 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, hist...
only quetiapine has been reported to show relatively equivalent efficacy in preventing both manic and depressive episodes [21,22]. Our results demonstrated that olanzapine was effective as prophylaxis treatment for the recurrence of depression. This finding is in contrast to previous reports which showed...
More recently, atypical antipsychotics have been used as monotherapy for bipolar depression. Efficacy was demonstrated in 2 randomized, placebo-controlled trials of quetiapine for treatment of depressive episodes in patients with bipolar I and bipolar II disorder [7, 8]. In contrast, efficacy was not...
Among antipsychotics, olanzapine has a higher risk for weight gain than the conventional antipsychotics haloperidol, chlorpromazine and fluphenazine, and its atypical counterparts risperidone, aripiprazole, sertindole, thioridazine, quetiapine, amisulpride, zotepine and ziprasidone (Allison et al., 1999; ...
Vieta E, Suppes T, Eggens I, Persson I, Paulsson B, Brecher M: Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008, 109 (3): 251-63. 10.1016/j.jad.2008.06.001....