quetiapine extended-release tablet dosed once daily at steady state has comparable bioavailability to an equivalent total daily dose of SEROQUEL administered in divided doses, twice daily. A high-fat meal (approximately 800 to 1000 calories) was found to produce statistically significant increases in ...
The results of a large retrospective cohort study appear to indicate that atypical antipsychotic agents (e.g., clozapine, olanzapine, risperidone, this drug) increase the risk of venous thromboembolism in elderly patients; however, these events seem to be rare....
Atypical antipsychotics, particularlyquetiapineand olanzapine, are also used with increasing frequency for insomnia. In contrast to the older antipsychotics that act primarily through blockade of dopamine type 2 receptors, the newer agents also act on a variety of receptors in addition, including antagoni...
405 in acute bipolar mania, 698 in bipolar depression, and 646 for the maintenance treatment of bipolar I disorder) were patients who participated in multiple dose effectiveness trials, and their experience corresponded to approximately 2400 patient-years. The conditions and duration of treatment with ...
Patients with hepatic impairment should be started on 25 mg/day. The dose should be increased daily in increments of 25 mg/day - 50 mg/day to an effective dose, depending on the clinical response and tolerability of the patient. Dose Modifications When Used With CYP3A4 Inhibitors ...
ROBERTSON J B JR ET AL: " Successful use of high dose quetiapine in a patient with a psychiatric disorder resistant to olanzapine. " EUROPEAN NEUROPSYCHOPHARMACOLOGY, vol. 10, no. Supplement 3, September 2000 (2000-09), pages S319-S320, XP001010838 13th Congress of the European College of ...
We compared charges for other mental health services associated with risperidone, olanzapine, and quetiapine treatment of patients with bipolar disorder to assess whether there were significant differences between these therapies. A secondary analysis involved dose-equivalent adjustment of the average allowed...
At a dose of 300 mg/day, quetiapine has been shown to be equivalent to haloperidol and chlorpromazine, but so far has not been shown to be comparable to clozapine for treatment-refractory patients. It is not known how quetiapine compares with the other first-line atypical antipsychotics (...
These doses are equivalent to 0.1, 0.5, 1.5, and 4.5 times the MRHD of 800 mg/day based on mg/m2 body surface area (mice) or 0.3, 1, and 3 times the MRHD based on mg/m2 body surface area (rats). There were statistically significant increases in thyroid gland follicular adenomas ...
And it was evaluated by comparing the peak areas of analytes and IS from blank extracts spiked after extraction to the mean area of the analytes and IS from neat solutions at equivalent concentration. 2.6.5. Stability The stability of the analytes were evaluated by analyzing low and high ...