Onset of action was generally similar among olanzapine long-acting injection, therapeutic doses of oral olanzapine, and oral haloperidol, based on a mean change in symptoms, and the magnitude of symptom reduction with 3 doses of the long-acting injection was similar to that with 10 to 15 mg...
BackgroundTo treat acute schizophrenia, a long-acting antipsychotic formulation needs a rapid onset of action and therapeutic profile similar to that of oral agents. The present analysescompared results from a fixed-dose, randomized, double-blind, placebo-controlled trial of olanzapine long-acting ...
BackgroundTo treat acute schizophrenia, a long-acting antipsychotic formulation needs a rapid onset of action and therapeutic profile similar to that of oral agents. The present analysescompared results from a fixed-dose, randomized, double-blind, placebo-controlled trial of olanzapine long-acting inje...
Olanzapine is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia.[Ref] Metabolic Oral formulations: Very common (10% or more): Weight gain/increased weight greater than/equal to 7% of baseline body weight (up to 89.4%), fasting ...
Olanzapine/fluoxetine (Symbyax®) is an oral once-daily fixed-dose combination of the atypical antipsychotic olanzapine and the selective serotonin reu
Oral ZYPREXA is indicated for the treatment of manic or mixed episodes associated with bipolar I disorderas an adjunct to lithium or valproate. Efficacy was established in two 6-week clinical trials in adults. The effectiveness of adjunctive therapy for longer-term use has not been systematically ...
Onset generally has ranged from soon after the injection to >3 hours after the injection; patients have largely recovered by 72 hours.Because the risk of PDSS is the same at each injection, the risk is cumulative (i.e., increases with the number of injections).FDA...
These cases implied that the short period (perhaps 3 days) after drug administration may be the peak of RAS onset. In addition, case 7 may be associated with psychiatric drugs, as oxcarbazepine would be used as a mood stabilizer in psychiatry. The patient in our case developed arm restless...
Olanzapine is well absorbed after oral administration in healthy volunteers and the absolute oral bioavailability (60 to 80%) is unaffected by food. Mean peak plasma concentrations (Cmax) of 11 μg/L after a single oral dose of 12.5mg are achieved in approximately 5 hours (tmax). Steady-stat...
weakness, hypertension, and convulsion. The potential for onset of an event is greatest within the first hour. The majority of cases have occurred within the first 3 hours after injection; however, the event has occurred after 3 hours. Following the 3-hour observation period, healthcare ...